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Astaxanthin Alleviates Aflatoxin B1-Induced Oxidative Stress and Apoptosis in IPEC-J2 Cells via the Nrf2 Signaling Pathway

文献类型： 外文期刊

作者： Tian, Yue 1 ; Che, Haoyu 1 ; Yang, Jinsheng 1 ; Jin, Yongcheng 1 ; Yu, Hao 1 ; Wang, Chuanqi 1 ; Fu, Yurong 1 ; Li, Na 2 ; Zhang, Jing 1 ;

作者机构： 1.Jilin Univ, Coll Anim Sci, Jilin Prov Key Lab Livestock & Poultry Feed & Feed, Changchun 130062, Peoples R China

2.Jilin Acad Agr Sci, Changchun 130033, Peoples R China

关键词： IPEC-J2 cells; aflatoxin B1; astaxanthin; oxidative stress; apoptosis; Nrf2 signaling pathway

期刊名称：TOXINS （ 影响因子：4.2； 五年影响因子：4.7 ）

ISSN：

年卷期： 2023 年 15 卷 3 期

页码：

收录情况： SCI

摘要： Aflatoxin B1 (AFB1), a typical fungal toxin found in feed, is highly carcinogenic. Oxidative stress is one of the main ways it exerts its toxicity; therefore, finding a suitable antioxidant is the key to reducing its toxicity. Astaxanthin (AST) is a carotenoid with strong antioxidant properties. The aim of the present research was to determine whether AST eases the AFB1-induced impairment in IPEC-J2 cells, and its specific mechanism of action. AFB1 and AST were applied to IPEC-J2 cells in different concentrations for 24 h. The AST (80 mu M) significantly prevented the reduction in the IPEC-J2 cell viability that was induced by AFB1 (10 mu M). The results showed that treatment with AST attenuated the AFB1-induced ROS, and cytochrome C, the Bax/Bcl2 ratio, Caspase-9, and Caspase-3, which were all activated by AFB1, were among the pro-apoptotic proteins which were diminished by AST. AST activates the Nrf2 signaling pathway and ameliorates antioxidant ability. This was further evidenced by the expression of the HO-1, NQO1, SOD2, and HSP70 genes were all upregulated. Taken together, the findings show that the impairment of oxidative stress and apoptosis, caused by the AFB1 in the IPEC-J2 cells, can be attenuated by AST triggering the Nrf2 signaling pathway.

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