Close association of PFASs exposure with hepatic fibrosis than steatosis: evidences from NHANES 2017-2018
文献类型: 外文期刊
作者: Cheng, Wenli 1 ; Li, Min 1 ; Zhang, Luyun 1 ; Zhou, Cheng 1 ; Zhang, Xinyu 1 ; Zhu, Chenyu 1 ; Tan, Luyi 1 ; Lin, Hui 3 ; Zhang, Wenjuan 1 ; Zhang, Wenji 2 ;
作者机构: 1.Jinan Univ, Sch Med, Dept Publ Hlth & Prevent Med, Guangzhou, Guangdong, Peoples R China
2.Guangdong Acad Agr Sci, Crops Res Inst, Guangdong Prov Engn & Technol Res Ctr Tobacco Bree, Key Lab Crop Genet Improvement Guangdong Prov, Guangzhou, Guangdong, Peoples R China
3.Guangdong Prov Peoples Hosp, Dept Radiat Oncol, Guangzhou, Guangdong, Peoples R China
4.Guangdong Acad Med Sci, Guangzhou, Guangdong, Peoples R China
5.Jinan Univ, Sch Med, Guangzhou, Guangdong, Peoples R China
关键词: Nonalcoholic fatty liver disease (NAFLD); Perfluoroalkyl and polyfluoroalkyl substances (PFASs); Generalized linear model (GLM); Restricted cubic spline (RCS); Bayesian kernel machine regression (BKMR)
期刊名称:ANNALS OF MEDICINE ( 影响因子:4.4; 五年影响因子:4.9 )
ISSN: 0785-3890
年卷期: 2023 年 55 卷 1 期
页码:
收录情况: SCI
摘要: Multiple animals and in vitro studies have demonstrated that perfluoroalkyl and polyfluoroalkyl substances (PFASs) exposure causes liver damage associated with fat metabolism. However, it is lack of population evidence for the correlation between PFAS exposure and nonalcoholic fatty liver disease (NAFLD). A cross-sectional analysis was performed of 1150 participants aged over 20 from the US. Liver ultrasound transient elastography was to identify the participants with NAFLD and multiple biomarkers were the indicators for hepatic steatosis and hepatic fibrosis. Logistics regression and restricted cubic splines models were used to estimate the association between PFASs and NAFLD. PFASs had not a significant association with NAFLD after adjustment. The hepatic steatosis indicators including fatty liver index, NAFLD liver fat score, and Framingham steatosis index were almost not significantly correlated with PFASs exposure respectively. But fibrosis indicators including fibrosis-4 index (FIB-4), NAFLD fibrosis score, and Hepamet fibrosis score were positively correlated with each type of PFASs exposure. After adjustment by gender, age, race, education, and poverty income rate, there was also a significant correlation between PFOS and FIB-4 with 0.07 (0.01, 0.13). The mixed PFASs were associated with FIB-4, with PFOS contributing the most (PIP = 1.000) by the Bayesian kernel machine regression model. The results suggested PFASs exposure appeared to be more closely associated with hepatic fibrosis than steatosis, and PFOS might be the main cause of PFASs associated with hepatic fibrosis. Key messages Current exposure doses of PFAS did not significantly change the risk of developing NAFLD. PFASs exposure appeared to be more closely associated with hepatic fibrosis than steatosis. PFOS might be the main cause of PFASs associated with hepatic fibrosis.
- 相关文献
作者其他论文 更多>>
-
New aspects characterizing non-obese NAFLD by the analysis of the intestinal flora and metabolites using a mouse model
作者:Zhang, Wenji;Huang, Zhenrui;Cheng, Wenli;Zhang, Wenjuan;Cheng, Wenli;Lin, Hui;Li, Jinghui
关键词:non-obese non-alcoholic fatty liver disease; intestinal flora; fecal metabolomics
-
Probiotic breakthrough: Clostridium butyricum improved the intestinal SCFAs content, digestive enzymes and antioxidant activities, gut morphology and microbiota composition of largemouth bass
作者:Chen, Xiaoying;Li, Peijia;Li, Min;Chen, Bing;Peng, Kai;Huang, Wen;Cao, Junming;Zhao, Hongxia;Li, Peijia
关键词:Clostridium butyricum; Largemouth bass; Growth performance; Intestinal health; Intestinal flora
-
Integrative proteome and metabolome unveil the central role of IAA alteration in axillary bud development following topping in tobacco
作者:Zou, Mingmin;Xu, Tingyu;Ma, Zhuwen;Li, Jiqin;Zhang, Wenji;Huang, Zhenrui;Pan, Xiaoying;Zhang, Dandan;Liu, Yixuan;Chen, Zepeng
关键词:Axillary bud; Proteome and metabolome; IAA; ROS; Tobacco
-
Key genes and immune infiltration patterns and the clinical implications in psoriasis patients
作者:Zhang, Xinyu;Tan, Luyi;Zhu, Chenyu;Li, Min;Cheng, Wenli;Zhang, Wenjuan;Zhu, Chenyu;Chen, Yibo;Zhang, Wenji
关键词:bioinformatics; differentially expressed genes (DEGs); inflammatory cells; psoriasis
-
Phytochemicals derived from Nicotiana tabacum L. plant contribute to pharmaceutical development
作者:Zhang, Wenji;Pan, Xiaoying;Huang, Zhenrui;Fu, Jiaqi;Cheng, Wenli;Zhang, Wenjuan;Lin, Hui;Lin, Hui
关键词:Nicotiana; neurodegeneration; inflammation; metabolic syndrome; nicotine; solaneso; cembranoid diterpenes; tobacco extracts
-
Effects of sodium butyrate on growth performance, antioxidant status, inflammatory response and resistance to hypoxic stress in juvenile largemouth bass (Micropterus salmoides)
作者:Hou, Dongqiang;Li, Min;Li, Peijia;Chen, Bing;Huang, Wen;Cao, Junming;Zhao, Hongxia;Hou, Dongqiang;Li, Min;Li, Peijia;Guo, Hui
关键词:sodium butyrate; largemouth bass; antioxidant system; inflammatory response; hypoxic stress
-
Association between perfluoroalkyl and polyfluoroalkyl internal exposure and serum a-Klotho levels in middle-old aged participants
作者:Li, Min;Cheng, Wenli;Zhang, Luyun;Zhou, Cheng;Zhang, Wenjuan;Li, Min;Zhang, Wenji;Ma, Yuanlin
关键词:perfluoroalkyl and polyfluoroalkyl substances (PFAS); alpha-Klotho; NHANES; perfluorononanoic acid (PFNA); middle-aged women