您好，欢迎访问新疆农业科学院 机构知识库！
新疆农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Protective role of RGS2 in PM2.5-induced ovarian injury in rats: Modulation of Gq/11 signaling to maintain granulosa cell [Ca2+]i stability

文献类型： 外文期刊

作者： Ma, Zhenhua 1 ; Du, Xiaohui 1 ; Zhao, Cuizhu 1 ; Sun, Yize 1 ; Jia, Yunna 1 ; Liang, Xiaojun 2 ; Yu, Xiuzhen 3 ; Gao, Yunhang 1 ;

作者机构： 1.Jilin Agr Univ, Coll Anim Sci & Technol, Changchun 130118, Peoples R China

2.Ningxia Acad Agr & Forestry, Inst Anim Sci, Yinchuan 750002, Peoples R China

3.Xinjiang Acad Agr Sci, Inst Agr Mechanizat, Urumqi 830091, Peoples R China

关键词： PM2.5; Premature ovarian failure; Regulator of G protein signaling 2; Ovarian granulosa cells; Gq/11; Intracellular Ca2+

期刊名称：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY （ 影响因子：6.1； 五年影响因子：6.4 ）

ISSN： 0147-6513

年卷期： 2025 年 302 卷

页码：

收录情况： SCI

摘要： Fine particulate matter (PM2.5) is toxic to reproduction and can cause a range of reproductive disorders. However, the mechanisms underlying female reproductive impairment due to PM2.5 exposure are unclear. In this study, we aimed to investigate the effects of PM2.5 on rat ovaries and the underlying molecular mechanisms. Animal models showed that PM2.5 exposure induced abnormal ovarian function and disturbed ovarian-related hormone homeostasis in rats, significantly increasing the proportion of follicular atresia. This process was accompanied by ovarian inflammation, oxidative stress, apoptosis, and damage to the intracellular calcium pool (endoplasmic reticulum). Regulators of G protein signaling (RGS) are thought to play an important role in ovarian physiology. We found abnormal expressed of RGS2 in PM2.5-induced ovarian damage. Overexpression of RGS2 via adeno-associated virus type 2/9 (AAV2/9) attenuated PM2.5-induced ovarian damage in rats. In addition, rat ovarian granulosa cells were extracted. In vitro experiments showed that RGS2 overexpression attenuated the harmful effects of PM2.5 on ovarian granulosa cells. In particular, RGS2 inhibited PM2.5-induced [Ca2+]i disturbances and the signaling of two G proteins (Gnaq, Gna11), and reduced the expression levels of PLC beta and IP3R. This process effectively maintained the stability of [Ca2+]i and ATP levels in ovarian granulosa cells. These data highlight the protective role of RGS2 in PM2.5-induced ovarian damage and provide new insights into the prevention and treatment of PM2.5-induced ovarian disease.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：新疆农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台