文献类型： 外文期刊
作者： Niu, Qiaoge 1 ; Zhou, Chuanjie 2 ; Li, Rui 2 ; Guo, Junqing 2 ; Qiao, Songlin 2 ; Chen, Xin-xin 2 ; Zhang, Gaiping 1 ;
作者机构： 1.Jilin Univ, Coll Vet Med, Changchun, Peoples R China
2.Henan Acad Agr Sci, Inst Anim Hlth, Key Lab Anim Immunol,Minist Agr, Zhengzhou, Peoples R China
3.Yangzhou Univ, Jiangsu Coinnovat Ctr Prevent & Control Important, Nanjing, Peoples R China
关键词： Baicalin; Pseudorabies virus; ROS; F3; NFU1; CEBPB
期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：7.7； 五年影响因子：7.7 ）
ISSN： 0141-8130
年卷期： 2024 年 277 卷
页码：
收录情况： SCI
摘要： Pseudorabies virus (PRV) poses a significant threat to livestock and even humans. Baicalin, a bioactive flavonoid glycoside with medicinal potential, has been reported to have various biological activities. However, its inhibitory effect on PRV remains poorly understood. In this study, we proved that baicalin effectively inhibits PRV infection. Proteomic analysis revealed that baicalin reduces the expression of 14 viral proteins, which are associated with virus replication, release and immune evasion. Furthermore, the abundance of 116 host proteins was altered by PRV infection, but restored to normal levels after treatment with baicalin. Pathway analysis indicated that baicalin mitigates reactive oxygen species (ROS) and suppresses abnormal mitochondrion by reducing the expression of NFU1 iron-sulfur cluster scaffold homolog (NFU1) protein induced by PRV. Notably, baicalin also activates the complete coagulation cascade by increasing the expression of coagulation factor III (F3) protein and enhances nucleoplasm by upregulating the expression of solute carrier family 3 member 2 (SLC3A2) and CCAAT enhancer binding protein beta (CEBPB) proteins, contributing to its inhibitory effects on PRV. Our findings implied that baicalin has the potential to be developed as an anti-PRV drug and provide insights into the underlying molecular basis.
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