Isolation, Purification, and Antioxidant Activity of Polyphenols from Cynanchum auriculatum Royle ex Wight
文献类型： 外文期刊
作者： Nasiru, Mustapha Muhammad 1 ; Sun, Yue-E 3 ; Zhao, Lingyun 3 ; Bunhok, Taing 2 ; Roth, Chuon Mony 2 ; Sovath, Sun 2 ; Pharith, Hay 2 ; Wang, Weidong 3 ; Li, Chunyang 1 ;
作者机构： 1.Jiangsu Acad Agr Sci, Inst Agroprod Proc, Nanjing 210014, Peoples R China
2.China Cambodia Joint Lab Detect & Funct Evaluat Nu, Phnom Penh 10103, Cambodia
3.Xuzhou Univ Technol, Sch Food & Biol Engn, Xuzhou 221018, Peoples R China
关键词： polyphenolic compounds; cynandione A; antioxidant assays; phenolic extraction; free radical scavenging; structural identification
期刊名称：SEPARATIONS （ 影响因子：2.7； 五年影响因子：2.7 ）
ISSN：
年卷期： 2024 年 11 卷 11 期
页码：
收录情况： SCI
摘要： Cynanchum auriculatum Royle ex Wight (CA) is a traditional medicinal and edible plant in China. This study aimed to isolate and characterize the phenolic compounds of C. auriculatum to identify its main antioxidant constituents. Polyphenols were extracted using an ultrasound-assisted ethanol extraction method, followed by partitioning with ethyl acetate. The ethyl acetate extract was then purified through thin-layer chromatography, silica gel column chromatography, and reverse-phase silica gel column chromatography. Three monomeric compounds-cynandione A (I), 2,5-dihydroxyacetophenone (II), and radix piperacanthone (III)-were identified through their physical and chemical properties, UV and IR spectra, and liquid chromatography-mass spectrometry (LC-MS/MS). Vitamin C (VC) and 2,4-dihydroxyacetophenone were used as controls to evaluate the antioxidant potential of the two most abundant monomers. Antioxidant assays demonstrated that 2,5-dihydroxyacetophenone and cynandione A exhibited strong antioxidant activity at lower concentrations, whereas 2,4-dihydroxyacetophenone showed significantly weaker activity. Furthermore, cynandione A displayed superior cellular antioxidant activity compared to 2,5-dihydroxyacetophenone, indicating its potential as a promising bioactive compound. In conclusion, this study provides valuable insights into the phenolic composition of C. auriculatum and highlights cynandione A as a key antioxidant, paving the way for future research on its therapeutic applications.
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