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Aeromonas hydrophila induces apoptosis in pufferfish, Takifugu obscurus

文献类型： 外文期刊

作者： Cheng, Chang-Hong 1 ; Guo, Zhi-Xun 1 ; Wang, An-Li 2 ;

作者机构： 1.Chinese Acad Fishery Sci, South China Sea Fisheries Res Inst, Key Lab Aquat Prod Proc, Minist Agr,Key Lab South China Sea Fishery Resour, Guangzhou 510300, Guangdong, Peoples R China

2.South China Normal Univ, Sch Life Sci, Key Lab Ecol & Environm Sci Guangdong Higher Educ, Guangdong Prov Key Lab Hlth & Safe Aquaculture, Guangzhou 510631, Guangdong, Peoples R China

关键词： Takifugu obscurus; Aeromonas hydrophila; apoptosis

期刊名称：ISRAELI JOURNAL OF AQUACULTURE-BAMIDGEH （ 影响因子：0.287； 五年影响因子：0.593 ）

ISSN： 0792-156X

年卷期： 2017 年 69 卷

页码：

收录情况： SCI

摘要： Aeromonas hydrophila is a Gram-negative opportunistic pathogen causing motile aeromonad septicemia, which results in great economic losses in freshwater fish farming. In this study, we investigated the effect of A. hydrophila on apoptosis of pufferfish blood cells. Total blood cell count, reactive oxygen species (ROS) production, cytoplasmic free-Ca2+ (cf-Ca2+) concentration, nitric oxide (NO) production, apoptotic cell ratio and the transcription levels of caspase-3 in the pufferfish blood cells were determined after A. hydrophila infection. Results showed that A. hydrophila infection significantly depressed the total blood cell count, and significantly increased ROS production, cf-Ca2+ concentration, NO production and apoptotic cell ratio. The transcription levels of caspase-3 increased significantly after A. hydrophila infection. Taken together, our results suggest that A. hydrophila infection alters ROS, cf-Ca2+, NO levels, and active caspase-3, which lead to cell apoptosis.

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