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Phylogenetic and molecular epidemiological studies reveal evidence of recombination among Marek's disease viruses

文献类型： 外文期刊

作者： He, Liangliang 1 ; Li, Jie 1 ; Zhang, Yun 1 ; Luo, Jun 3 ; Cao, Yongchang 1 ; Xue, Chunyi 1 ;

作者机构： 1.Sun Yat Sen Univ, Sch Life Sci, State Key Lab Biocontrol, Guangzhou 510006, Guangdong, Peoples R China

2.Changshu Inst Technol, Sch Biol & Food Engn, Changshu 215500, Jiangsu, Peoples R China

3.Henan Acad Agr Sci, Key Lab Anim Immunol, Henan Prov Key Lab Anim Immunol, Minist Agr, Zhengzhou 450002, Henan, Peoples R China

4.Henan Univ Sci & Technol, Coll Anim Sci & Technol, Luoyang 471003, Peoples R China

关键词： MDV; Complete genome; Phylogenetic analysis; Evolution; Recombination

期刊名称：VIROLOGY （ 影响因子：3.616； 五年影响因子：3.967 ）

ISSN： 0042-6822

年卷期： 2018 年 516 卷

页码：

收录情况： SCI

摘要： Marek's disease has brought enormous loss in chicken production worldwide and the increasing virulence of Marek's disease virus (MDV) became a severe problem. To better understand the genetic basis underlying, a Chinese MDV strain HNGS101 isolated from immunized chickens was sequenced. Phylogenetic analysis implied that HNGS101 showed more relatedness to Eurasian strains than GaHV-2 circulating in North America. Recombination networks analysis showed the evidence of recombination among MDV strains, and several recombination events in the UL and US region were found. Further analysis indicated that the HNGS101 strain seemed to be generated by the recombination of the earliest Eurasian strains and North American strains in the US region, which may be responsible for the MD outbreaks in China. In summary,this is the first report to demonstrate recombination events among MDV strains, which may shed light on the mechanism of virulence enhancement.

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