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Immune escape of avian oncogenic Marek's disease herpesvirus and antagonistic host immune responses

文献类型： 外文期刊

作者： Zhu, Zhi-Jian 1 ; Teng, Man 3 ; Liu, Yu 1 ; Chen, Fu-Jia 1 ; Yao, Yongxiu 7 ; Li, En-Zhong 1 ; Luo, Jun 3 ;

作者机构： 1.Huanghuai Univ, Coll Biol & Food Engn, Zhumadian 463000, Peoples R China

2.Huanghuai Univ, Affiliated Cent Hosp, Zhumadian 463000, Peoples R China

3.Henan Acad Agr Sci, Inst Anim Hlth, Zhengzhou 450002, Peoples R China

4.Henan Acad Agr Sci, UK China Ctr Excellence Res Avian Dis, Zhengzhou 450002, Peoples R China

5.Henan Acad Agr Sci, Henan Prov Key Lab Anim Immunol, Zhengzhou 450002, Peoples R China

6.Minist Agr & Rural Affairs Peoples Republ China, Key Lab Anim Immunol, Zhengzhou 450002, Peoples R China

7.Pirbright Inst, Ash Rd, Guildford GU24 0NF, England

8.UK China Ctr Excellence Res Avian Dis, Ash Rd, Guildford GU24 0NF, England

9.Henan Univ Sci & Technol, Coll Anim Sci & Technol, Lab Funct Microbiol & Anim Hlth, Luoyang 471003, Peoples R China

10.Longhu Lab, Zhengzhou 450046, Peoples R China

期刊名称：NPJ VACCINES （ 影响因子：6.9； 五年影响因子：6.7 ）

ISSN：

年卷期： 2024 年 9 卷 1 期

页码：

收录情况： SCI

摘要： Marek's disease virus (MDV) is a highly pathogenic and oncogenic alpha herpesvirus that causes Marek's disease (MD), which is one of the most important immunosuppressive and rapid-onset neoplastic diseases in poultry. The onset of MD lymphomas and other clinical diseases can be efficiently prevented by vaccination; these vaccines are heralded as the first demonstration of a successful vaccination strategy against a cancer. However, the persistent evolution of epidemic MDV strains towards greater virulence has recently resulted in frequent outbreaks of MD in vaccinated chicken flocks worldwide. Herein, we provide an overall review focusing on the discovery and identification of the strategies by which MDV evades host immunity and attacks the immune system. We have also highlighted the decrease in the immune efficacy of current MD vaccines. The prospects, strategies and new techniques for the development of efficient MD vaccines, together with the possibilities of antiviral therapy in MD, are also discussed.

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