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DDX3X and virus interactions: functional diversity and antiviral strategies

文献类型： 外文期刊

作者： Ma, Shengming 1 ; Mao, Qian 1 ; Weng, Shaoting 1 ; Teng, Man 2 ; Luo, Jun 2 ; Zhang, Kunpeng 1 ;

作者机构： 1.Anyang Inst Technol, Henan Joint Int Res Lab Vet Biol Res & Applicat, Anyang, Peoples R China

2.Henan Acad Agr Sci, Inst Anim Hlth & UK, China Ctr Excellence Res Avian Dis, Zhengzhou, Peoples R China

关键词： DDX3X; virus; immune response; molecular interaction; cross-species heterogeneity

期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：4.5； 五年影响因子：5.2 ）

ISSN：

年卷期： 2025 年 16 卷

页码：

收录情况： SCI

摘要： As a core member of the DEAD-box helicase family, DDX3X modulates RNA metabolic networks through its ATPase activity, RNA helicase function, and nucleic acid-binding capacity to participate in bidirectional regulation of innate immune responses and virus-host interactions. Multiple viruses achieve effective genome replication and immune evasion by hijacking DDX3X's enzymatic activities or interfering with its mediated immune signaling transduction. Nevertheless, hosts have evolved strategies to exploit DDX3X for activating interferon signaling pathways and other antiviral mechanisms, establishing multilayered defense networks. This review systematically elaborates the functional diversity exhibited by DDX3X protein in virus interaction networks. DDX3X orchestrates viral genomic RNA processing during replication. Simultaneously, it interacts with host restriction factors to evade antiviral immunity, establishing a dynamic balance between viral propagation and host defense. The functional plasticity of DDX3X not only elucidates immune regulatory mechanisms in host-pathogen coevolution, but also provides novel molecular perspectives for deciphering zoonotic transmission barriers.

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