您好，欢迎访问河南省农业科学院 机构知识库！
河南省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Deoxynivalenol induces testicular ferroptosis by regulating the Nrf2/ System Xc-/GPX4 axis

文献类型： 外文期刊

作者： Yang, Xu 1 ; Huang, Tingyu 1 ; Chen, Yunhe 1 ; Chen, Fengjuan 1 ; Liu, Yu 1 ; Wang, Youshuang 1 ; Song, Wenxi 1 ; Zhang, Juntao 1 ; Jiang, Yibao 3 ; Wang, Fangyu 4 ; Zhang, Cong 1 ;

作者机构： 1.Henan Agr Univ, Coll Vet Med, Zhengzhou 450002, Henan, Peoples R China

2.Henan Agr Univ, Coll Vet Med, Int Joint Res Ctr Natl Anim Immunol, Zhengzhou 450046, Peoples R China

3.Henan Agr Univ, Coll Anim Sci & Technol, Zhengzhou 450046, Henan, Peoples R China

4.Henan Acad Agr Sci, Key Lab Anim Immunol, Zhengzhou, Henan, Peoples R China

5.Minist Agr & Rural Affairs, Key Lab Qual & Safety Control Poultry Prod, Beijing, Peoples R China

6.Henan Agr Univ, Coll Vet Med, 15 Longzihu Univ Pk, Zhengzhou 450046, Peoples R China

关键词： Deoxynivalenol; Testis; Ferroptosis; Nrf2 pathway; Lipid peroxidation

期刊名称：FOOD AND CHEMICAL TOXICOLOGY （ 影响因子：4.3； 五年影响因子：5.1 ）

ISSN： 0278-6915

年卷期： 2023 年 175 卷

页码：

收录情况： SCI

摘要： Deoxynivalenol (DON) is the most common mycotoxin contaminant in food and feed. DON accumulation in food chain severely threatens human and animal health due to the toxic effects on the reproduction system. However, the underlying mechanism of DON on male reproductive dysfunction is still in debate and there is little infor-mation about whether DON triggers testicular ferroptosis. In this study, male C57BL/6 mice were divided into 4 groups and treated by oral gavage with 0, 0.5, 1.0, 2.0 mg/kg BW DON for 28 days. Firstly, we proved that male reproduction dysfunction was induced by DON through assessing testicular histopathology, serum testosterone level as well as blood-testis barrier integrity. Then, we verified ferroptosis occurred in DON-induced testicular dysfunction model through disrupting iron homeostasis, increasing lipid peroxidation and inhibiting system Xc/ Gpx4 axis. Notably, the present data showed DON reduced antioxidant capacity via blocking Nrf2 pathway to lead to the further weakness of ferroptosis resistance. Altogether, these results indicated that DON caused mice testicular ferroptosis associated with inhibiting Nrf2/System Xc-/GPx4 axis, which provided that maintaining testicular iron homeostasis and activating Nrf2 pathway may be a potential target for alleviating testicular toxicity of DON in the future.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：河南省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台