Pea Peptides and Heavy Metal Neurotoxicity: Exploring Mechanisms and Mitigation Strategies in PC12 Cells
文献类型： 外文期刊
作者： Li, Ning 1 ; Cui, Ningning 1 ; Li, Tiange 1 ; Zhao, Peijun 1 ; Bakry, Ibrahim A. 1 ; Li, Qian 1 ; Cheng, Yongxia 1 ; Galaverna, Gianni 2 ; Yang, Huijie 1 ; Wang, Fangyu 2 ;
作者机构： 1.Henan Agr Univ, Coll Food Sci & Technol, 63 Agr Rd, Zhengzhou 450000, Peoples R China
2.Henan Acad Agr Sci, Key Lab Anim Immunol, 116 HuaYuan Rd, Zhengzhou 450002, Peoples R China
3.Univ Parma, Food & Drug Dept, Parco Area Sci 17 A, I-43124 Parma, Italy
关键词： Pea peptide; Calsyntenin-1; Lead; PC12; Alzheimer's disease
期刊名称：PLANT FOODS FOR HUMAN NUTRITION （ 影响因子：3.6； 五年影响因子：4.1 ）
ISSN： 0921-9668
年卷期： 2025 年 80 卷 1 期
页码：
收录情况： SCI
摘要： Calsyntenin-1 (Clst1) is a sensitive indicator of lead (Pb) toxicity in neural tissue. This study was designed to investigate the impact of lead exposure on Clst1 expression in PC12 cells and the mitigating effect of pea peptide 4 (PP4) on lead-induced neurotoxicity. Data showed that lead exposure, at varying doses and durations, disrupted the mRNA expression and protein levels of Clstn1 in PC12 cells. However, immunofluorescence results showed that treatment with PP4 significantly increased Clstn1 protein expression in the Pb + PP4 and PP4 groups compared to the Pb groups (P < 0.05). Lead exposure activates the JNK and p38 pathways; at the same time, PP4 treatment enhances ERK pathway activation and reduces JNK and p38 activation.
- 相关文献
作者其他论文 更多>>
-
Black soybean peptide mediates the AMPK/SIRT1/NF-κB signaling pathway to alleviate Alzheimer's-related neuroinflammation in lead-exposed HT22 cells
作者：Yang, Huijie;Zhao, Peijun;Ullah, Saif;Ma, Yan;Zhao, Guangshan;Cheng, Yongxia;Li, Qian;Li, Tiange;Qiao, Mingwu;Song, Lianjun;Zhang, Lei;Huang, Xianqing;Li, Ning;Wang, Fangyu;Galaverna, Gianni
关键词：Black soybean peptide; Lead (Pb); Alzheimer's disease; Neuroinflammation; AMPK/SIRT1/NF-kappa B pathway
-
Development of a Paper-Based Microfluidic Chip for Point-of-Care Detection of PEDV
作者：Li, Renfeng;Cao, Wenyan;Jiang, Jiaxin;Yuan, Jiakang;Li, Linyue;Wang, Ziliang;Tian, Xiangqin;You, Yonghe;Zhou, Yanlin;Wang, Fangyu
关键词：porcine epidemic diarrhea virus; loop-mediated isothermal amplification; paper-based microfluidic analytical device; point-of-care detection
-
Pea Peptide Modulates Abnormal Aβ Production in PC12 Cells Induced by Lead Exposure
作者：Li, Ning;Cui, Ningning;Bakry, Ibrahim A.;Ma, Yan;Cheng, Yongxia;Zhao, Guangshan;Yang, Huijie;Song, Lianjun;Qiao, Mingwu;Hai, Dan;Galaverna, Gianni;Huang, Xianqing
关键词：Lead; Pea peptide; APP; BACE1; A beta(1-42); PI3K/AKT
-
In Vitro Protective Effect of Pea-Derived Peptides (PPs) via the Keap1/Nrf2 Signaling Pathway on Alpha-Gliadin-Sensitizing Peptide Induced Cacao-2 Cells
作者：Gao, Bing;Yan, Fang;Wang, Chunfeng;Cui, Chenxu;Sun, Xuefeng;Wang, Fangyu;Li, Ning
关键词：antioxidant enzymes; celiac disease; free radicals scavenging; alpha-gliadin peptide; Keap1/Nrf2 pathway
-
Development of a visual detection method of porcine deltacoronavirus using loop-mediated isothermal amplification
作者：Li, Renfeng;Cao, Wenyan;Yuan, Jiakang;Li, Linyue;Wang, Ziliang;Zhou, Yanlin;Wang, Fangyu;Tian, Xiangqin
关键词：porcine; deltacoronavirus; loop-mediated isothermal amplification; visualization; detection
-
Utilization of Antiviral Peptides in Treating Coronavirus Infection: An Overview
作者：Xu, Qian;Zhang, Gaiping;Xu, Qian;Wang, Fangyu;Feng, Hua;Wei, Qiang;Sun, Xuefeng;Xing, Guangxu;Zhang, Gaiping;Zhang, Gaiping;Zhang, Gaiping;Zhang, Gaiping
关键词：Coronaviruses; Viral infection; Natural peptides; Synthetic peptides; Antiviral therapeutics
-
Machine Learning-Driven Methods for Nanobody Affinity Prediction
作者：Feng, Hua;Sun, Xuefeng;Xu, Qian;Li, Qin;Zhang, Shenli;Xing, Guangxu;Zhang, Gaiping;Wang, Fangyu;Feng, Hua;Wang, Fangyu;Li, Ning;Zhang, Gaiping;Zhang, Gaiping
关键词：
