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Utilization of Antiviral Peptides in Treating Coronavirus Infection: An Overview

文献类型： 外文期刊

作者： Xu, Qian 1 ; Wang, Fangyu 2 ; Feng, Hua 2 ; Wei, Qiang 2 ; Sun, Xuefeng 2 ; Xing, Guangxu 2 ; Zhang, Gaiping 1 ;

作者机构： 1.Northwest A&F Univ, Coll Vet Med, Dept Prevent Vet Med, Yangling 712100, Shaanxi, Peoples R China

2.Henan Acad Agr Sci, Key Lab Anim Immunol, 116 Huayuan Rd, Zhengzhou 450002, Peoples R China

3.Longhu Modern Immunol Lab, Zhengzhou 450046, Henan, Peoples R China

4.Peking Univ, Sch Adv Agr Sci, Beijing, Peoples R China

5.Yangzhou Univ, Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou, Jiangsu, Peoples R China

关键词： Coronaviruses; Viral infection; Natural peptides; Synthetic peptides; Antiviral therapeutics

期刊名称：INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS （ 影响因子：2.4； 五年影响因子：2.0 ）

ISSN： 1573-3149

年卷期： 2024 年 31 卷 1 期

页码：

收录情况： SCI

摘要： Purpose of ReviewThis review aims to elucidate the mechanisms employed by antiviral peptides in inhibiting coronaviruses as well as related limitations their therapeutic applications, and how to address the limitations faced as potential drugs in targeted therapy infectious diseases.Recent FindingsThe epidemic of MERS-CoV, SARS-CoV or COVID-19 have attracted more attention due to its the high mortality rate, among which, SARS-CoV-2 infections led that more than 625 million confirmed cases and more than 6 million deaths, the mortality rate of MERS-CoV reached 35.5%, SARS CoV reached 10%, although various vaccines and antiviral drugs have been researched and developed, their efficacy is still limited by the emerging SARS-CoV-2 strains. Novel molecules (peptides) are short polycationic antivirals with widely effects, which has unique advantages compared with large proteins and small molecules, such as their biocompatibility, low side effects and target selectivity. Many of them have been verified that therapeutic actions against reported animal coronaviruses such as PEDV, TGEV, IBV or human coronavirus such as MERS-CoV, SARS-CoV, COVID-19.SummaryConfronted with complex and changeable infectious diseases, although antiviral peptides are less used in clinical applications, especially in animal husbandry, they can be used as an auxiliary means to assist vaccines in preventing and controlling the spread of infectious diseases. This has largely eased the pressure on vaccine development, making them promising candidates for future medicine development.

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