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Polychlorinated Diphenylsulfides Activate Aryl Hydrocarbon Receptor 2 in Zebrafish Embryos: Potential Mechanism of Developmental Toxicity

文献类型： 外文期刊

作者： Zhang, Rui 1 ; Wang, Xiaoxiang 2 ; Zhang, Xuesheng 4 ; Song, Chao 5 ; Letcher, Robert J. 7 ; Liu, Chunsheng 9 ;

作者机构： 1.Univ Jinan, Sch Resources & Environm, Jinan 250022, Shandong, Peoples R China

2.Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resources Reuse, Nanjing 210023, Jiangsu, Peoples R China

3.Assoc Chinese Chemists & Chem Engineers Germany, D-67117 Limburgerhof, Germany

4.Anhui Univ, Sch Resources & Environm Engn, Hefei 230601, Anhui, Peoples R China

5.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Wuxi 214081, Peoples R China

6.Minist Agr, Lab Qual & Safety Risk Assessment Aquat Prod Envi, Wuxi 214081, Peoples R China

7.Carleton Univ, Dept Chem, Ottawa, ON K1S 5B6, Canada

8.Carleton Univ, Dept Biol, Ottawa, ON K1S 5B6, Canada

9.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China

期刊名称：ENVIRONMENTAL SCIENCE & TECHNOLOGY （ 影响因子：9.028； 五年影响因子：9.922 ）

ISSN： 0013-936X

年卷期： 2018 年 52 卷 7 期

页码：

收录情况： SCI

摘要： It is hypothesized that polychlorinated diphenyl sulfides (PCDPSs) induce lethal toxicity in zebrafish which is mediated by aryl hydrocarbon receptor 2 (Ahr2) activation. In this study an assay was developed based on in vivo exposure of wild-type and Tg(cyp1a:gfp) transgenic zebrafish embryos/larvae to PCDPS congeners (i.e., six dichloro- to heptachlorodiphenyl sulfides) coupled with a zebrafish Ahr2-luciferase reporter gene (LRG) expression. Waterborne PCDPSs were found to be accumulated in zebrafish larvae, and exposure to PCDPSs led to a significant increase in mortality and cyp1s mRNA expression. Furthermore, treatment with PCDPSs caused a significant induction of Ahr2-LRG activity in COS-7 cells, and extremely significant correlations were observed between the in vivo median lethal concentrations and the levels of cyp1s mRNA expression and Ahr2 activation. Molecular dynamics simulations indicated the interaction between dioxins/dioxin-like compounds (DLCs) and six key amino acid residues in the ligand-binding domain of Ahr2 probably determined the susceptibility to dioxins/DLCs in zebrafish. These results strongly support the hypothesis that early life-stage mortality of zebrafish is initiated and mediated by Ahr2 activation.

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