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A soybean cyst nematode suppresses microbial plant symbionts using a lipochitooligosaccharide-hydrolysing enzyme

文献类型： 外文期刊

作者： Chen, Wei 1 ; Wang, Di 1 ; Ke, Shaoyong 3 ; Cao, Yangrong 4 ; Xiang, Wensheng 1 ; Guo, Xiaoli 5 ; Yang, Qing 1 ;

作者机构： 1.Chinese Acad Agr Sci, State Key Lab Biol Plant Dis & Insect Pests, Inst Plant Protect, Beijing, Peoples R China

2.Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Minist Agr & Rural Affairs, Shenzhen Branch,Guangdong Lab Lingnan Modern Agr, Shenzhen, Peoples R China

3.Hubei Acad Agr Sci, Natl Biopesticide Engn Res Ctr, Hubei Biopesticide Engn Res Ctr, Key Lab Microbial Pesticides,Minist Educ & Rural A, Wuhan, Peoples R China

4.Huazhong Agr Univ, Coll Life Sci & Technol, Natl Key Lab Agr Microbiol, Hubei Hongshan Lab, Wuhan, Peoples R China

5.Huazhong Agr Univ, Coll Plant Sci & Technol, Natl Key Lab Agr Microbiol, Wuhan, Peoples R China

期刊名称：NATURE MICROBIOLOGY （ 影响因子：20.5； 五年影响因子：21.0 ）

ISSN： 2058-5276

年卷期： 2024 年 9 卷 8 期

页码：

收录情况： SCI

摘要： Cyst nematodes are the most damaging species of plant-parasitic nematodes. They antagonize the colonization of beneficial microbial symbionts that are important for nutrient acquisition of plants. The molecular mechanism of the antagonism, however, remains elusive. Here, through biochemical combined with structural analysis, we reveal that Heterodera glycines, the most notorious soybean cyst nematode, suppresses symbiosis by secreting an enzyme named HgCht2 to hydrolyse the key symbiotic signalling molecules, lipochitooligosaccharides (LCOs). We solved the three-dimensional structures of apo HgCht2, as well as its chitooligosaccharide-bound and LCO-bound forms. These structures elucidated the substrate binding and hydrolysing mechanism of the enzyme. We designed an HgCht2 inhibitor, 1516b, which successfully suppresses the antagonism of cyst nematodes towards nitrogen-fixing rhizobia and phosphorus-absorbing arbuscular mycorrhizal symbioses. As HgCht2 is phylogenetically conserved across all cyst nematodes, our study revealed a molecular mechanism by which parasitic cyst nematodes antagonize the establishment of microbial symbiosis and provided a small-molecule solution. Heterodera glycines, a soybean cyst nematode, suppresses microbial plant symbiosis by secreting the HgCht2 enzyme to hydrolyse the key symbiotic signalling molecules, lipochitooligosaccharides.

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