Hepatoprotective effects of Lactobacillus plantarum C88 on LPS/D-GalN-induced acute liver injury in mice
文献类型： 外文期刊
作者： Duan, Cuicui 1 ; Zhao, Yujuan 1 ; Huang, Cheng 1 ; Zhao, Zijian 1 ; Gao, Lei 1 ; Niu, Chunhua 1 ; Wang, Chao 1 ; Liu, Xia 1 ;
作者机构： 1.Jilin Acad Agr Sci, Inst Agrofood Technol, 1363 Sheng Tai St, Changchun 130033, Jilin, Peoples R China
2.Jilin Acad Agr Sci, Inst Agr Qual Stand & Testing Technol, Changchun 130033, Jilin, Peoples R China
3.Jilin Univ, Dept Endocrinol, Hosp 2, Changchun 130000, Jilin, Peoples R China
关键词： Lactobacillus plantarum; Hepatoprotective; Antioxidation; Anti-inflammation; Intestinal barrier
期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：4.451； 五年影响因子：4.907 ）
ISSN： 1756-4646
年卷期： 2018 年 43 卷
页码：
收录情况： SCI
摘要： Acute liver failure (ALF) is a life-threatening clinical condition resulting from massive apoptosis of hepatocytes. This study aims to examine the protective effects of Lactobacillus plantanun C88 on LPS/D-GalN-induced ALF and elucidate its underlying molecular mechanisms in mice. The results showed that L. plantarum C88 pretreatment significantly reduced the levels of plasma ALT and AST in mice with LPS/D-GalN-induced liver injury. L. plantation C88 pretreatment decreased the secretion of inflammatory cytokines. In addition, L. plantarum C88 remarkably increased the expression levels and nuclear translocations of Nrf2 mRNA in liver tissues, but inhibited NF-kappa B nuclear translocations and P65, P38 phosphorylation levels. Moreover, L. plantarum C88 enhanced the intestinal mucosa] barrier by upregulating the expressions of tight junction proteins as well as HIF-1 alpha. These results suggest that L. plantarum C88 protects against ALF associated with Nrf2 and the MAPK/NF-kappa B signaling pathways.
- 相关文献
作者其他论文 更多>>
-
Utilization of hyaluronic acid to improve Mozzarella cheese: Composition, texture, microstructure, and pizza baking properties
作者：Jiao, Yufu;Gao, Lei;Kang, You;Gao, Yansong;Zhao, Yujuan;Zhao, Zijian;Yang, Ge;Li, Shengyu;Jiao, Yufu;Gao, Lei;Kang, You;Gao, Yansong;Zhao, Yujuan;Zhao, Zijian;Yang, Ge;Li, Shengyu
关键词：Hyaluronic acid; Mozzarella cheese; Physicochemical; Microstructure; Pizza bake
-
Psoralen and Isopsoralen Activate Nuclear Factor Erythroid 2-Related Factor 2 Through Interaction With Kelch-Like ECH-Associated Protein 1
作者：Lv, Chengyu;Wang, Song;Sun, Chang;Chen, Yihao;Wang, Chao;Yuan, Cuiping;Qin, Fengxian;Li, Tiezhu;Liu, Jing
关键词：antioxidant response element; isopsoralen; molecular docking; Nrf2; psoralen
-
Anti-colorectal cancer effect of total minor ginsenosides produced by lactobacilli transformation of major ginsenosides by inducing apoptosis and regulating gut microbiota
作者：Shen, Yunjiao;Gao, Yansong;Yang, Ge;Zhao, Zijian;Zhao, Yujuan;Gao, Lei;Li, Shengyu;Shen, Yunjiao
关键词：ginsenoside; lactic acid bacteria; minor ginsenosides; apoptosis; anti-cancer; gut microbiota
-
Optimization of Tropane Alkaloids Extraction from Anisodus luridus Utilizing Response Surface Methodology and Quality Assessment through UPLC Fingerprinting
作者：Zhang, Baoxin;Jiang, Na;Xie, Hongjun;Lan, Xiaozhong;Zhang, Baoxin;Tian, Jingqin;Jiang, Na;Chai, Guozhu;Quan, Hong;Han, Xinghao;Lan, Xiaozhong;Zhang, Fangyuan;Liao, Zhihua;Chen, Min;Wang, Chao
关键词：
-
Genetic variation in the aquaporin TONOPLAST INTRINSIC PROTEIN 4;3 modulates maize cold tolerance
作者：Zeng, Rong;Zhang, Xiaoyan;Li, Minze;Fu, Diyi;Zhang, Zhuo;Gao, Lei;Zhang, Shuaisong;Yang, Xiaohong;Tian, Feng;Yang, Shuhua;Shi, Yiting;Song, Guangshu;Lv, Qingxue;Yang, Xiaohong;Tian, Feng
关键词：cold stress; maize; TIP4;3; natural variation; stomatal movement; reactive oxygen species
-
Transformation of Ginsenosides by Lactiplantibacillus plantarum MB11 Fermentation: Minor Ginsenosides Conversion and Enhancement of Anti-Colorectal Cancer Activity
作者：Shen, Yunjiao;Gao, Yansong;Yang, Ge;Zhao, Zijian;Zhao, Yujuan;Gao, Lei;Li, Shengyu;Shen, Yunjiao;Zhao, Lei
关键词：probiotic; Lactiplantibacillus plantarum; anticancer; ginsenosides; apoptosis; autophagy
-
Cellulase with Bacillus velezensis improves physicochemical characteristics, microbiota and metabolites of corn germ meal during two-stage co-fermentation
作者：Chen, Long;Guo, Yang;Liu, Xin;Zheng, Lin;Wei, Bingdong;Zhao, Zijian
关键词：Nutritional value; Two-stage solid-state fermentation; Microbial diversity; Fermented feed
