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Comparison of the virulence of three H3N2 canine influenza virus isolates from Korea and China in mouse and Guinea pig models

文献类型： 外文期刊

作者： Xie, Xing 1 ; Na, Woonsung 2 ; Kang, Aram 2 ; Yeom, Minjoo 2 ; Yuk, Heejun 2 ; Moon, Hyoungjoon 4 ; Kim, Sung-jae 4 ; Kim 1 ;

作者机构： 1.Nanjing Agr Univ, Coll Vet Med, Joint Int Res Lab Anim Hlth & Food Safety, Nanjing 210095, Jiangsu, Peoples R China

2.Korea Univ, Coll Pharm, Sejong 339700, South Korea

3.Jiangsu Acad Agr Sci, Inst Vet Med, Key Lab Vet Biol Engn & Technol, Minist Agr, 50 Zhongling St, Nanjing 210014, Jiangsu, Peoples R China

4.Green Cross Vet Prod, Res Unit, Yongin 17066, South Korea

5.Seoul Natl Univ, Coll Vet Med, Dept Vet Med, Virol Lab, Seoul 08826, South Korea

6.Seoul Natl Univ, Sch Agr Biotechnol, Program Vet Sci BK21, Seoul 08826, South Korea

7.Konkuk Univ, Coll Vet Med, Small Anim Tumor Diagnost Ctr, Dept Vet Pathol, 120 Neundong Ro, Seoul 143701, South Korea

8.Jiangsu Acad Agr Sci, Inst Food Safety & Nutr, 50 Zhongling St, Nanjing 210014, Jiangsu, Peoples R China

关键词： H3N2 canine influenza virus; Pathogenicity; Transmissibility; BALB/c mice; Guinea pigs

期刊名称：BMC VETERINARY RESEARCH （ 影响因子：2.741； 五年影响因子：2.955 ）

ISSN： 1746-6148

年卷期： 2018 年 14 卷

页码：

收录情况： SCI

摘要： Background: Avian-origin H3N2 canine influenza virus (CIV) has been the most common subtype in Korea and China since 2007. Here, we compared the pathogenicity and transmissibility of three H3N2 CIV strains [Chinese CIV (JS/10), Korean CIV (KR/07), and Korean recombinant CIV between the classic H3N2 CIV and the pandemic H1N1 virus (MV/12)] in BALB/c mouse and guinea pig models. The pandemic H1N1 (CA/09) strain served as the control. Results: BALB/c mice infected with H1N1 had high mortality and obvious body weight loss, whereas no overt disease symptoms were observed in mice inoculated with H3N2 CIV strains. The viral titers were higher in the group MV/12 than those in groups JS/10 and KR/07, while the mice infected with JS/10 showed higher viral titers in all tissues (except for the lung) than the mice infected with KR/07. The data obtained in guinea pigs also demonstrated that group MV/12 presented the highest loads in most of the tissues, followed by group JS/10 and KR/07. Also, direct contact transmissions of all the three CIV strains could be observed in guinea pigs, and for the inoculated and the contact groups, the viral titer of group MV/12 and KR/07 was higher than that of group JS/10 in nasal swabs. These findings indicated that the matrix (M) gene obtained from the pandemic H1N1 may enhance viral replication of classic H3N2 CIV; JS/10 has stronger viral replication ability in tissues as compared to KR/07, whereas KR/07 infected guinea pigs have more viral shedding than JS/ 10 infected guinea pigs. Conclusions: There exists a discrepancy in pathobiology among CIV isolates. Reverse genetics regarding the genomes of CIV isolates will be helpful to further explain the virus characteristics.

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