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Selection of Avibacterium paragallinarum Page serovar B strains for an infectious coryza vaccine

文献类型： 外文期刊

作者： Sun, Huiling 1 ; Xie, Sanlei 1 ; Li, Xiaofei 1 ; Xu, Fuzhou 1 ; Li, Yi 2 ; Boucher, Charlotte E. 3 ; Chen, Xiaoling 1 ;

作者机构： 1.Beijing Acad Agr & Forestry Sci, Beijing Key Lab Prevent & Control Infect Dis Live, Inst Anim Husb & Vet Med, 9 Shuguang Huayuan Zhonglu, Beijing 100097, Peoples R China

2.Beijing E Feed & E Vet Cooperat, Beijing 100029, Peoples R China

3.Univ Free State, Fac Nat & Agr Sci, Dept Microbial Biochem & Food Biotechnol, ZA-9300 Bloemfontein, Sou

关键词： Avibacterium paragallinarum; Infectious coryza; Page serovar B; Cross-protection

期刊名称：VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY （ 影响因子：2.046； 五年影响因子：2.217 ）

ISSN： 0165-2427

年卷期： 2018 年 199 卷

页码：

收录情况： SCI

摘要： Infectious coryza is an important respiratory disease of chickens around the world and is caused by Avibacterium paragallinarum. Among the three Page serovars currently recognized for this bacterium, serovar B is a major circulating serovar in China nowadays. The cross-protection ability of the Page serovar B reference strain (0222) and five local isolates was evaluated by a vaccination-challenge trial in SPF chickens. The clinical signs seen in control birds challenged by strain 0222 and isolate HB 01 were significantly different, with isolate HB 01 giving more severe clinical signs. In terms of cross-protection, the protection in the groups vaccinated with isolate HB 01 and BJ 02 was significantly higher than that in the groups vaccinated with 0222 and the other three isolates. In addition, an experimental oil adjuvant trivalent vaccine, containing field isolate HB 01 antigen, was compared for immune efficacy with two commercial trivalent infectious coryza vaccines containing internationally recognized serovar B strains. The experimental oil adjuvant trivalent vaccine elicited best protection (80%) among the three trivalent vaccines. In conclusion, the oil adjuvant vaccine, containing field isolate HB 01 may be a better choice in control of current serovar B Av. paragallinarum outbreaks in China under current circumstances.

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