Long-term exposure of two plasticizers di (2-ethylhexyl) phthalate (DEHP) and acetyl tributyl citrate (ATBC): toxic effects on gonadal development and reproduction of zebrafish ("Danio rerio")
文献类型： 外文期刊
作者： Muhammad, Shafi 1 ; Zhang, Zheng 3 ; Pavase, Tushar Ramesh 4 ; Guo, Huarong 1 ;
作者机构： 1.Ocean Univ China, Minist Educ, Key Lab Marine Genet & Breeding, Qingdao 266003, Peoples R China
2.Ocean Univ China, Inst Evolut & Marine Biodivers, Qingdao 266003, Peoples R China
3.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Qingdao 266071, Peoples R China
4.Ocean Univ China, Coll Food Sci & Engn, Lab Food Safety, Qingdao 266003, Shandong, Peoples R China
关键词： Plasticizer; DEHP; ATBC; Reproductive toxicity; Zebrafish
期刊名称：INDIAN JOURNAL OF GEO-MARINE SCIENCES （ 影响因子：0.496； 五年影响因子：0.605 ）
ISSN： 0379-5136
年卷期： 2018 年 47 卷 4 期
页码：
收录情况： SCI
摘要： Present study investigated the exposure effects of two plasticizers, di (2-ethylhexyl) phthalate (DEHP) and acetyl tributyl citrate (ATBC) on the gonadal development and reproduction in zebrafish (Danio rerio) at environmentally relevant concentration (0.5 mu g/L) for six months by comparing with the control group. We observed the significant adverse effects of two plasticizers in the embryos and larvae of zebrafish resulting inhibition of body length, weight and gonado-somatic index (GSI) in both exposed male and female zebrafish with impaired fecundity. Histological analysis revealed the apparent inhibition of ovaries in zebrafish after six months DEHP exposure. Present study reveals that the DEHP phthalate can adversely affect the reproduction and functioning in the male and female zebrafish compared to the ATBC exposure which showed relatively low effects.
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