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Effects of Lactobacillus reuteri LR1 on the growth performance, intestinal morphology, and intestinal barrier function in weaned pigs

文献类型： 外文期刊

作者： Yi, Hongbo 1 ; Wang, Li 1 ; Xiong, Yunxia 1 ; Wen, Xiaolu 1 ; Wang, Zhilin 2 ; Yang, Xuefen; Gao, Kaiguo; Jiang, Zo 1 ;

作者机构： 1.Guangdong Acad Agr Sci, Guangdong Publ Lab Anim Breeding & Nutr,Key Lab A, Guangdong Key Lab Anim Breeding & Nutr,Inst Anim, State Key Lab Livestock & Poultry Breeding,Minist, 1 Dafeng 1st St, Guangzhou 510640, Guangdong, Peoples R China

2.Guangdong Acad Agr Sci, Guangdong Publ Lab Anim Breeding & Nutr,Key

关键词： antibiotics; intestinal barrier function; Lactobacillus reuteri LR1; weaned pig

期刊名称：JOURNAL OF ANIMAL SCIENCE （ 影响因子：3.159； 五年影响因子：2.912 ）

ISSN： 0021-8812

年卷期： 2018 年 96 卷 6 期

页码：

收录情况： SCI

摘要： The objective of this study was to investigate the effects of Lactobacillus reuteri LR1, a new strain isolated from the feces of weaned pigs, on the growth performance, intestinal morphology, immune responses, and intestinal barrier function in weaned pigs. A total of 144 weaned pigs (Duroc x Landrace x Yorkshire, 21 d of age) with an initial BW of 6.49 +/- 0.02 kg were randomly assigned to 3 dietary treatments with 8 replicate pens, each of per treatment and 6 pigs. Pigs were fed a basal diet (CON, controls), the basal diet supplemented with 100 mg/kg olaquindox and 75 mg/kg aureomycin (OA) or the basal diet supplemented with 5 x 10(10) cfu/kg L. reuteri LR1 for a 14-d period. At the end of study, the ADG, ADFI, and G:F were calculated, and 1 randomly selected pig from each pen was euthanized for sample collection. The LR1 increased ADG (22.73%, P < 0.05) compared with CON. The villus height of the ileum was increased (P < 0.05) and crypt depth in duodenum was reduced (P < 0.05), along with increased (P < 0.05) villus height to crypt depth ratio of the jejunum and ileum by LR1 compared with CON and OA. LR1 increased (P < 0.05) ileal mucosal content of IL-22 and transforming growth factor-ss compared with OA. Compared with CON, LR1 increased (P < 0.05) and OA decreased (P < 0.05) the ileal content of secretory immunoglobulin A (sIgA), and the abundance of transcripts of porcine ss-defensin 2 and protegrin 1-5. Compared with CON, LR1 increased (P < 0.05) tight junction protein zonula occludens-1 and occludin transcripts in the mucosa of the jejunum and ileum, and those of mucin-2 in ileal mucosa. The relative expression of toll-like receptor 2 (TLR2) and TLR4 were increased (P < 0.05) in ileal mucosa in pigs fed LR1 compared with CON. In conclusion, these data indicated that dietary LR1 supplementation at 5 x 10(10) cfu/kg improved growth performance, intestinal morphology, and intestinal barrier function in weaned pigs.

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