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Analysis of Ran related to pesticide resistance in Drosophila Kc cells

文献类型： 外文期刊

作者： Bo, Qian 1 ; Chen, Lu 1 ; Liu, Yahui 1 ; Chang, Chunjie 1 ; Ying, Xiaoli 1 ; Li, Fengliang 2 ; Cheng, Luogen 1 ;

作者机构： 1.Nanjing Normal Univ, Coll Life Sci, Jiangsu Key Lab Biodivers & Biotechnol, Nanjing 210023, Jiangsu, Peoples R China

2.Guizhou Acad Agr Sci, Inst Plant Protect, Guiyang 550009, Guizhou, Peoples R China

关键词： Ran; Pesticide; Stress; Resistance

期刊名称：GENE （ 影响因子：3.688； 五年影响因子：3.329 ）

ISSN： 0378-1119

年卷期： 2018 年 663 卷

页码：

收录情况： SCI

摘要： Pesticides have been used extensively for pest control, resulting in serious pesticide resistance. It is extremely valuable to identify the resistance genes related to pest control. In our previous studies, we reported that Ran is the deltamethrin (DM) resistance-associated gene. To clarify whether Ran is also related to the resistance of other pesticides, we selected four kinds of pesticides, including parathion, DDT, carbaryl and pleocidin, for further study. The results showed that Ran could be up-regulated by all pesticides. We further verified the relationship between Ran and resistance to the 4 pesticides by Ran RNAi, Ran overexpression and cell apoptosis. We found that the dsRNA of Ran induced more cell apoptosis than the control. Ran overexpression can significantly improve cell tolerance to various pesticides. These results demonstrate that Ran is associated with the resistance to and tolerance of multiple pesticides. Our evidence suggests the Ran is a potential molecular target gene of resistance control.

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