Novel wound dressing with chitosan gold nanoparticles capped with a small molecule for effective treatment of multiantibiotic-resistant bacterial infections
文献类型： 外文期刊
作者： Lu, Bitao 1 ; Ye, Hongli 1 ; Shang, Songmin 2 ; Xiong, Qinqin 1 ; Yu, Kun 1 ; Li, Qing 1 ; Xiao, Yang 3 ; Dai, Fangyin 1 ; L 1 ;
作者机构： 1.Southwest Univ, Coll Text & Garments, Chongqing 400715, Peoples R China
2.Hong Kong Polytech Univ, Inst Text & Clothing, Hong Kong, Hong Kong, Peoples R China
3.Guangdong Acad Agr Sci, Sericulture & Agri Food Res Inst, Guangzhou 510610, Guangdong, Peoples R China
4.Chongqing Engn Res Ctr Biomat Fiber & Modern Text, Chongqing 400715, Peoples R China
关键词： gold nanoparticles; 2-mercapto-1-methylimidazole; CS; antibacterial activity; wound dressing
期刊名称：NANOTECHNOLOGY （ 影响因子：3.874； 五年影响因子：3.618 ）
ISSN： 0957-4484
年卷期： 2018 年 29 卷 42 期
页码：
收录情况： SCI
摘要： Wound infection caused by multiantibiotic-resistant bacteria has become a serious problem, and more effective antibacterial agents are required. Herein, we report the preparation of wound dressings using the biocompatible chitosan (CS) as a reducing and stabilizing agent in the synthesis of 2-mercapto-1-methylimidazole (MMT)-capped gold nanocomposites (CSAu@MMT), with efficient antibacterial effects. The synergistic effects of AuNPs, MMT, and CS led to the disruption of bacterial membranes. After blending with gelatin, crosslinking with tannin acid, and freeze-drying, CS-gelatin (CS-Au@MMT/gelatin) dressing was prepared. It had good mechanical properties as well as efficient water absorption and retention capacities. It exhibited outstanding biocompatibility both in vitro and in a cell-based wound infection model. Moreover, the in vivo rabbit wound healing model revealed that the CS-Au@MMT/gelatin dressing possesses significant antibacterial potential against methicillin-resistant Staphylococcus aureus-associated wound infection. Therefore, the CS-Au@MMT/gelatin dressing described in this study may have huge potential in biomedical applications.
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