Highly Stable and NIR Luminescent Ru-LPMSN Hybrid Materials for Sensitive Detection of Cu2+ in Vivo
文献类型： 外文期刊
作者： Chen, Fangman 1 ; Xiao, Fangnan 2 ; Zhang, Weibing 1 ; Lin, Chentao 4 ; Wu, Yunkun 2 ;
作者机构： 1.Chinese Acad Sci, Fujian Inst Res Struct Matter, State Key Lab Struct Chem, Fuzhou 350002, Fujian, Peoples R China
2.Fujian Normal Univ, Provincial Univ Key Lab Cellular Stress Response, Coll Life Sci, Key Lab OptoElect Sci & Technol Med,Minist Educ, Fuzhou 350119, Fujian, Peoples R China
3.Fujian Agr & Forestry Univ, Sch Life Sci, Fuzhou 350002, Fujian, Peoples R China
4.Fujian Acad Agr Sci, Inst Biotechnol, Dept Immunol, Fuzhou 350003, Fujian, Peoples R China
关键词： ruthenium complex; LPMSN; Cu2+; in vivo
期刊名称：ACS APPLIED MATERIALS & INTERFACES （ 影响因子：9.229； 五年影响因子：9.57 ）
ISSN： 1944-8244
年卷期： 2018 年 10 卷 32 期
页码：
收录情况： SCI
摘要： Herein, new near-infrared (NIR) luminescent ruthenium complexes were prepared for detecting Cu2+ ions. Then, ruthenium complex hybrid nanomaterials (Ru-LPMSNs) were fabricated successfully by imbedding the ruthenium complex into mesoporous silica nanoparticles. Benefiting from the novel large-pore mesoporous structure and good adsorbility of LPMSNs, Ru-LPMSN hybrid materials showed a significantly enhanced fluorescence intensity and stability. NIR fluorescence of Ru LPMSNs was rapidly quenched by Cu2+ ions. Ru LPMSNs also showed high Cu2+ ion selectivity and sensitivity as a sensor. The detection limit of Cu2+ ions was 10 nM with a wide linear relationship between the fluorescence intensity of Ru LPMSNs and the concentration of Cu2+ ions. The mechanism of fluorescence quenching might be that the combination of the ruthenium complex and Cu2+ ions constrained the photoinduced electron-transfer process. Furthermore, Ru LPMSNs dramatically increased the fluorescence signals in cells and achieved Cu2+-ion detection. Ru LPMSNs had different tissue affinities and could monitor distribution of exogenous Cu2+ ions in vivo. Moreover, Ru LPMSNs realized direct and rapid detection of Cu2+-ion content in serum. These results indicated the potential applications of the prepared nanomaterials as Cu2+ detection agents.
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