您好，欢迎访问广东省农业科学院 机构知识库！
广东省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Polymorphisms of ABCG2 and its impact on clinical relevance

文献类型： 外文期刊

作者： Zhang, Wenji 1 ; Sun, Shili 3 ; Zhang, Wenjuan 4 ; Shi, Zhi 1 ;

作者机构： 1.Jinan Univ, Coll Life Sci & Technol, Guangdong Prov Key Lab Bioengn Med, Natl Engn Res Ctr Genet Med,Dept Cell Biol, Guangzhou 510632, Guangdong, Peoples R China

2.Jinan Univ, Coll Life Sci & Technol, Guangdong Prov Key Lab Bioengn Med, Natl Engn Res Ctr Genet Med,Inst Biomed, Guangzhou 510632, Guangdong, Peoples R China

3.Guangdong Acad Agr Sci, Tea Res Inst, Guangdong Prov Key Lab Tea Plant Resources Innova, Dafeng Rd 6, Guangzhou 510640, Guangdong, Peoples R China

4.Jinan Univ, Sch Med, Dept Toxicol, Guangzhou 510632, Guangdong, Peoples R China

关键词： ABCG2; SNPs; Gout; Cancer; Epilepsy; Atorvastatin; Alzheimer's disease

期刊名称：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS （ 影响因子：3.575； 五年影响因子：3.381 ）

ISSN： 0006-291X

年卷期： 2018 年 503 卷 2 期

页码：

收录情况： SCI

摘要： Human ABCG2 is one of the most important ATP-binding cassette (ABC) transporters. This protein functions as a xenobiotic transporter of large, hydrophobic, positively or negatively charged molecules, a wide variety anticancer drugs, fluorescent dyes, and different toxic compounds found in normal food. SNPs in ABCG2 may affect absorption and distribution of these substrates, altering the accumulation, effectiveness and toxicity of compounds or drugs in large populations. Its transport properties have been implicated clinically and ABCG2 expression is linked with different disease states. We reviewed the SNPs of ABCG2 in clinical relevance about gout, acute myeloid leukemia, solid tumors, and other diseases. (C) 2018 Elsevier Inc. All rights reserved.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：广东省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台