文献类型： 外文期刊
作者： Zhang, Wenji 1 ; Sun, Shili 3 ; Zhang, Wenjuan 4 ; Shi, Zhi 1 ;
作者机构： 1.Jinan Univ, Coll Life Sci & Technol, Guangdong Prov Key Lab Bioengn Med, Natl Engn Res Ctr Genet Med,Dept Cell Biol, Guangzhou 510632, Guangdong, Peoples R China
2.Jinan Univ, Coll Life Sci & Technol, Guangdong Prov Key Lab Bioengn Med, Natl Engn Res Ctr Genet Med,Inst Biomed, Guangzhou 510632, Guangdong, Peoples R China
3.Guangdong Acad Agr Sci, Tea Res Inst, Guangdong Prov Key Lab Tea Plant Resources Innova, Dafeng Rd 6, Guangzhou 510640, Guangdong, Peoples R China
4.Jinan Univ, Sch Med, Dept Toxicol, Guangzhou 510632, Guangdong, Peoples R China
关键词： ABCG2; SNPs; Gout; Cancer; Epilepsy; Atorvastatin; Alzheimer's disease
期刊名称：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS （ 影响因子：3.575； 五年影响因子：3.381 ）
ISSN： 0006-291X
年卷期： 2018 年 503 卷 2 期
页码：
收录情况： SCI
摘要： Human ABCG2 is one of the most important ATP-binding cassette (ABC) transporters. This protein functions as a xenobiotic transporter of large, hydrophobic, positively or negatively charged molecules, a wide variety anticancer drugs, fluorescent dyes, and different toxic compounds found in normal food. SNPs in ABCG2 may affect absorption and distribution of these substrates, altering the accumulation, effectiveness and toxicity of compounds or drugs in large populations. Its transport properties have been implicated clinically and ABCG2 expression is linked with different disease states. We reviewed the SNPs of ABCG2 in clinical relevance about gout, acute myeloid leukemia, solid tumors, and other diseases. (C) 2018 Elsevier Inc. All rights reserved.
- 相关文献
作者其他论文 更多>>
-
Mechanism of Green Tea Peptides in Lowering Blood Pressure and Alleviating Renal Injury Induced by Hypertension Through the Ang II/TGF-β1/SMAD Signaling Pathway
作者：Li, Lulu;Li, Dongli;Li, Lulu;Sun, Shili;Lai, Xingfei;Li, Qiuhua;Chen, Ruohong;Zhang, Zhenbiao;Hao, Mengjiao;Zhang, Suwan;Sun, Lingli;Li, Dongli
关键词：tea polypeptide; hypertension; renal injury; TGF-beta/Smad signaling
-
RNA m7G methylation regulators and targets significantly contribute to chronic obstructive pulmonary disease
作者：Zhu, Chenyu;Tan, Luyi;Zhang, Xinyu;Cheng, Wenli;Li, Min;Zhang, Wenjuan;Chen, Yibo
关键词：COPD; m7G; METTL1; CAT; Bioinformatics analysis
-
Metabolomics-based analysis of the effects of differences in soluble sugars on the sweetness quality of six major tea types in China
作者：Li, Wen;Chen, Zhongzheng;Zhang, Zhenbiao;Chen, Ruohong;Sun, Lingli;Lai, Xingfei;Li, Qiuhua;Hao, Mengjiao;Zhang, Suwang;Sun, Shili;Li, Qian
关键词：
-
Global m6A RNA and whole 5mC DNA methylation specifically contribute to cell replicative and premature senescence induced by extrinsic oxidative stress
作者：Zhu, Chenyu;Huang, Tingting;Fu, Jiaqi;Li, Min;Tan, Luyi;Zhang, Xinyu;Cheng, Wenli;Lai, Caiyun;Zhang, Wenjuan;Wang, Zhangying;Zhang, Wenji
关键词：H2O2; N6-methyladenosine; 5-methylcytosine; premature senescence; epigenetics
-
Effects of Pile-Fermentation Duration on the Taste Quality of Single-Cultivar Large-Leaf Dark Tea: Insights from Metabolomics and Microbiomics
作者：Yang, Wanying;Ni, He;Chen, Ruohong;Sun, Lingli;Li, Qiuhua;Lai, Xingfei;Zhang, Zhenbiao;Lai, Zhaoxiang;Hao, Mengjiao;Sun, Shili;Li, Qian;Lin, Sen
关键词：dark tea; quality; taste; pile-fermentation; metabolomics; microbiomics
-
Analysis of volatile metabolites and differences in aroma quality of green tea, black tea and oolong tea prepared from highly aromatic tea variety (Dancong)
作者：Zhang, Suwan;Xia, Hongling;Sun, Shili;Ma, Chenying;Pan, Shunshun;Zhang, Zhenbiao;Lai, Xingfei;Li, Qiuhua;Hao, Mengjiao;Sun, Lingli;Chen, Ruohong;Zhang, Suwan;Xia, Hongling;Sun, Shili;Ma, Chenying;Pan, Shunshun;Zhang, Zhenbiao;Lai, Xingfei;Li, Qiuhua;Hao, Mengjiao;Sun, Lingli;Chen, Ruohong;Li, Feng;Ma, Chenying
关键词：Fermentation degree; Tea; Aroma; VOCs; GC-MS
-
Inhibition of xanthine oxidase by copper-gallate coordination polymers and its mechanistic study
作者：Mo, Yejian;Ren, Jian;Sun, Shili;Shen, Xiaoyu;Mo, Yejian;Ren, Jian;Liu, Kexin;Deng, Chunlin;Shen, Xiaoyu;Mo, Yejian;Ren, Jian;Liu, Kexin;Deng, Chunlin
关键词：Hyperuricemia; Metal-polyphenol coordination polymers; Xanthine oxidase inhibitors; Antioxidant properties
