您好，欢迎访问中国水产科学研究院 机构知识库！
中国水产科学研究院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

0# Diesel water-accommodated fraction induced lipid homeostasis alteration in zebrafish embryos

文献类型： 外文期刊

作者： Mu, Xiyan 1 ; Liu, Jia 1 ; Yang, Ke 1 ; Huang, Ying 1 ; Li, Xuxing 1 ; Yang, Wenbo 1 ; Qi, Suzhen 2 ; Tu, Wenqing 3 ; Shen, 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Fishery Resource & Environm Res Ctr, Beijing, Peoples R China

2.Chinese Acad Agr Sci, Inst Apicultural Res, Beijing, Peoples R China

3.Jiangxi Acad Sci, Res Inst Poyang Lake, Nanchang 330012, Jiangxi, Peoples R China

关键词： Diesel; Zebrafish embryos; Lipid metabolism; Lipid homeostasis; Mortality

期刊名称：ENVIRONMENTAL POLLUTION （ 影响因子：8.071； 五年影响因子：8.35 ）

ISSN： 0269-7491

年卷期： 2018 年 242 卷

页码：

收录情况： SCI

摘要： To investigate the developmental effects and corresponding molecular mechanism of diesel in freshwater organisms, zebrafish embryos were exposed to 0# diesel water-accommodated fraction (WAF) at different concentrations. Mortality, embryonic morphological endpoints, transcriptional profile and lipid profile were evaluated after exposure. Exposure to 0# diesel WAF had no significant effect on the survival of zebrafish embryos from 1.5 to 96 hpf. However, a significant increase in mortality was observed at 144 and 196 hpf in the groups of 20 and 40 mg/L 0# diesel WAF. RNA-Seq results demonstrated that 0# diesel WAF could induce significant alterations in transcription profile at concentrations of 0.05 mg/L (the limit for petroleum hydrocarbon concentration in surface water in China) and 5 mg/L. Gene Ontology enrichment and similarity analysis indicated that lipid metabolism, lipid synthesis, biological transport, drug metabolism and homeostatic processes were the most altered biological processes after exposure to 0# diesel WAF. Further, transcription levels of genes involved in cholesterol and fatty acid synthesis were significantly inhibited by diesel WAF according to qPCR results. Lipidomics results also indicated that several lipid species (cholesterol ester, fatty acid, diglyceride and triglyceride) decreased after 0# diesel WAF exposure. These results reflect the potential risk of diesel pollution in freshwater ecosystems especially on the alteration of lipid homeostasis and enable a better understanding of the molecular pathways underlying the action of diesel WAF in zebrafish embryos. (C) 2018 Elsevier Ltd. All rights reserved.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：中国水产科学研究院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台