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Comparative disinfection efficacy in aquaculture: novel methylene bis(thiocyanate) vs. conventional trichloroisocyanuric acid against Aeromonas hydrophila

文献类型： 外文期刊

作者： Yang, Guang 1 ; Huang, Ying 2 ; Ma, Ning 2 ; Li, Kai 2 ; Wang, Xiao-mei 2 ; Zhang, Lian-bo 1 ; Yang, Wen-bo 2 ; Zhang, Wan-li 2 ; Xia, Lei 3 ; Zhang, Hong-Yu 2 ; Yuan, Li-lai 2 ;

作者机构： 1.Chinese Acad Fishery Sci, Fisheries Engn Inst, Beijing, Peoples R China

2.Chinese Acad Fishery Sci, Fishery Resource & Environm Res Ctr, Beijing, Peoples R China

3.Chinese Acad Fishery Sci, Beijing, Peoples R China

关键词： Aeromonas; methylene bis (thiocyanate); trichloroisocyanuric acid; disinfection; aquaculture

期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：4.5； 五年影响因子：5.2 ）

ISSN：

年卷期： 2025 年 16 卷

页码：

收录情况： SCI

摘要： Aeromonas hydrophila is a major pathogen responsible for significant economic losses in global aquaculture. Inhibitory and bactericidal activities of seven disinfectants were tested against 10 aquatic pathogens, including A. hydrophila, A. veronii, A. salmonicida, A. sobria, Edwardsiella tarda, E. ictaluri, Pseudomonas aeruginosa, and Yersinia ruckeri. Minimal effective concentrations were determined via quantitative suspension tests, while a scale-trauma zebrafish model assessed in vivo protection. Methylene bis(thiocyanate) (MBT) exhibited the strongest antimicrobial activity, with minimum inhibitory concentrations and minimum bactericidal concentrations of 0.1-0.4 mg/L and 0.2-0.8 mg/L, respectively. At 0.01 mg/L, MBT achieved a 3-log pathogen inactivation, equivalent to 0.2 mg/L Trichloroisocyanuric acid (TCCA). In vivo, 0.01 mg/L MBT provided 100% protection in zebrafish after 6 and 12 h exposure, whereas 0.2 mg/L TCCA yielded 95.83 +/- 3.61% survival after 1 h. The safe concentrations of MBT and TCCA for zebrafish were 0.0364 and 0.0677 mg/L, respectively. The results showed that both TCCA and MBT effectively controlled A. hydrophila infection; however, MBT demonstrated greater potential for aquaculture applications due to its lower effective concentration (0.01 mg/L) and reduced sensitivity to interference from organic matter. In addition, this study presents a systematic protocol for evaluating the efficacy of disinfectants.

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