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Low warfarin resistance frequency in Norway rats in two cities in China after 30 years of usage of anticoagulant rodenticides

文献类型： 外文期刊

作者： Ma, Xiaohui 1 ; Wang, Dawei 1 ; Li, Ning 1 ; Liu, Lan 1 ; Tian, Lin 1 ; Luo, Chan 3 ; Cong, Lin 3 ; Feng, Zhiyong 4 ; Liu, X 1 ;

作者机构： 1.Chinese Acad Agr Sci, State Key Lab Biol Plant Dis & Insect Pests, Inst Plant Protect, Beijing 100193, Peoples R China

2.Sichuan Univ, Coll Life Sci, Chengdu, Sichuan, Peoples R China

3.Heilongjiang Acad Agr Sci, Inst Plant Protect, Harbin, Heilongjiang, Peoples R China

4.Guangdong Acad Agr Sci, Plant Protect Res Inst, Guangzhou, Guangdong, Peoples R China

关键词： Norway rat; anticoagulant rodenticides; resistance; vitamin K epoxide reductase complex; subunit 1 (Vkorc1); polymorphisms; standardized blood clotting reaction (BCR); lethal feeding period (LFP)

期刊名称：PEST MANAGEMENT SCIENCE （ 影响因子：4.845； 五年影响因子：4.674 ）

ISSN： 1526-498X

年卷期： 2018 年 74 卷 11 期

页码：

收录情况： SCI

摘要： BACKGROUND: Anticoagulant rodenticides have been widely used in rodent control in China for >30 years and resistant Norway rats have been reported. Mutations in the vitamin K epoxide reductase complex, subunit 1 (Vkorc1) gene can cause anticoagulant resistance in rodents. In this study, we analyzed the Vkorc1 polymorphisms of 681 Norway rats collected in Zhanjiang and Harbin Cities in China from 2008 to 2015 and evaluated the warfarin resistance frequency. RESULTS: Analysis revealed four mutations, including three not previously reported. Two new synonymous mutations, His68His and Leu105Leu, are not associated with warfarin resistance. One new nonsynonymous mutation, Ala140Thr, was found in Zhanjiang rat samples collected in 3 years with low frequencies (3.3-4.0%) and is probably associated with warfarin resistance. Laboratory resistance tests suggested low warfarin resistance frequencies in rats from Zhanjiang (4.9-17.1%) and Harbin (0-2.5%) Cities. CONCLUSIONS: Both genetic analysis and laboratory resistance tests suggested low warfarin resistance frequencies in rats from Zhanjiang and Harbin Cities. The alternate usage of first-generation anticoagulant rodenticides (FGARs) and second-generation anticoagulant rodenticides (SGARs) might represent an effective strategy against the development of warfarin resistance in Norway rats in China. (C) 2018 Society of Chemical Industry

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