文献类型： 外文期刊

作者： Liu, Ming ¹ ; Yu, Caixia ⁴ ; Zhang, Zhichao ⁷ ; Song, Mingjing ⁹ ; Sun, Xiuping ⁹ ; Pialek, Jaroslav ¹⁰ ; Jacob, Jens ¹¹ ; Lu, Jiqi ¹² ; Cong, Lin ¹³ ; Zhang, Hongmao ¹⁴ ; Wang, Yong ¹⁵ ; Li, Guoliang ¹ ; Feng, Zhiyong ¹⁷ ; Du, Zhenglin ⁴ ; Wang, Meng ⁷ ; Wan, Xinru ¹ ; Wang, Dawei ¹⁸ ; Wang, Yan-Ling ³ ; Li, Hongjun ¹ ; Wang, Zuoxin ¹⁹ ; Zhang, Bing ⁴ ; Zhang, Zhibin ¹ ;

作者机构： 1.Chinese Acad Sci, Inst Zool, State Key Lab Integrated Management Pest Insects, Beijing, Peoples R China

2.Int Soc Zool Sci, Beijing, Peoples R China

3.Chinese Acad Sci, Inst Zool, State Key Lab Stem Cell & Reprod Biol, Beijing, Peoples R China

4.Chinese Acad Sci, Beijing Inst Genom, Beijing, Peoples R China

5.China Natl Ctr Bioinformat, Beijing, Peoples R China

6.Chinese Acad Sci, Natl Genom Data Ctr, Beijing Inst Genom, Beijing, Peoples R China

7.Novogene Bioinformat Inst, Beijing, Peoples R China

8.Glbizzia Biosci, Beijing, Peoples R China

9.Chinese Acad Med Sci, Inst Lab Anim Sci, Beijing, Peoples R China

10.Czech Acad Sci, Res Facil Studenec, House Mouse Grp, Inst Vertebrate Biol, Brno, Czech Republic

11.Julius Kuhn Inst, Inst Plant Protect Hort & Forests, Fed Res Ctr Cultivated Plants, Inst Epidemiol & Pathogen Diagnost, Munster, Germany

12.Zhengzhou Univ, Sch Life Sci, Zhengzhou, Henan, Peoples R China

13.Heilongjiang Acad Agr Sci, Inst Plant Protect, Harbin, Heilongjiang, Peoples R China

14.Cent China Normal Univ, Sch Life Sci, Wuhan, Hubei, Peoples R China

15.Chinese Acad Sci, Inst Subtrop Agr, Changsha, Hunan, Peoples R China

16.Univ Chinese Acad Sci, CAS Ctr Excellence Biot Interact, Beijing, Peoples R China

17.Guangdong Acad Agr Sci, Plant Protect Res Inst, Guangzhou, Guangdong, Peoples R China

18.Chinese Acad Agr Sci, Inst Plant Protect, Beijing, Peoples R China

19.Florida State Univ, Dept Psychol, Tallahassee, FL 32306 USA

20.Florida State Univ, Program Neurosci, Tallahassee, FL 32306 USA

关键词： Mus musculus; Domestication; Positively selected gene; Genome sequencing; Alternative splicing

期刊名称：GENOME BIOLOGY （ 影响因子：17.906； 五年影响因子：20.367 ）

ISSN： 1474-760X

年卷期： 2022 年 23 卷 1 期

页码：

收录情况： SCI

摘要： Background The laboratory mouse was domesticated from the wild house mouse. Understanding the genetics underlying domestication in laboratory mice, especially in the widely used classical inbred mice, is vital for studies using mouse models. However, the genetic mechanism of laboratory mouse domestication remains unknown due to lack of adequate genomic sequences of wild mice. Results We analyze the genetic relationships by whole-genome resequencing of 36 wild mice and 36 inbred strains. All classical inbred mice cluster together distinctly from wild and wild-derived inbred mice. Using nucleotide diversity analysis, Fst, and XP-CLR, we identify 339 positively selected genes that are closely associated with nervous system function. Approximately one third of these positively selected genes are highly expressed in brain tissues, and genetic mouse models of 125 genes in the positively selected genes exhibit abnormal behavioral or nervous system phenotypes. These positively selected genes show a higher ratio of differential expression between wild and classical inbred mice compared with all genes, especially in the hippocampus and frontal lobe. Using a mutant mouse model, we find that the SNP rs27900929 (T>C) in gene Astn2 significantly reduces the tameness of mice and modifies the ratio of the two Astn2 (a/b) isoforms. Conclusion Our study indicates that classical inbred mice experienced high selection pressure during domestication under laboratory conditions. The analysis shows the positively selected genes are closely associated with behavior and the nervous system in mice. Tameness may be related to the Astn2 mutation and regulated by the ratio of the two Astn2 (a/b) isoforms.