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Lactobacillus brevis 23017 Relieves Mercury Toxicity in the Colon by Modulation of Oxidative Stress and Inflammation Through the Interplay of MAPK and NF-kappa B Signaling Cascades

文献类型： 外文期刊

作者： Jiang, Xinpeng 1 ; Gu, Shanshan 1 ; Liu, Di 2 ; Zhao, Lili 3 ; Xia, Shuang 1 ; He, Xinmiao 2 ; Chen, Hongyan 4 ; Ge, Junw 1 ;

作者机构： 1.Northeast Agr Univ, Coll Vet Med, Heilongjiang Key Lab Anim Dis Control & Pharmaceu, Harbin, Heilongjiang, Peoples R China

2.Minist Agr, Heilongjiang Acad Agr Sci, Anim Husb Res Inst, Key Lab Combining Farming & Anim Husb, Harbin, Heilongjiang, Peoples R China

3.Chinese Acad Agr Sci, Harbin Vet Res Inst, Heilongjiang Prov Key Lab Lab Anim & Comparat Med, State Key Lab Vet Biotechnol, Harbin, Heilongjiang, Peoples R China

4.Chinese Acad Agr Sci, Harbin Vet Res Inst, Heilongjiang Prov Key Lab Lab Anim & Comparat Me

关键词： Lactobacillus brevis; mercury; oxidative stress; inflammation; MAPK; NF-kappa B

期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：5.64； 五年影响因子：6.32 ）

ISSN： 1664-302X

年卷期： 2018 年 9 卷

页码：

收录情况： SCI

摘要： Aims: Lactobacillus strains have protective effects against heavy metals while relieving oxidative stress and modulating the immune response. Mechanisms that ameliorate heavy metal toxicity and the relationship between probiotics and gut barrier protection in the process of heavy metal pathogenesis was poorly understood. Methods and Results: In this study, Lactobacillus brevis 23017 (LAB, L. brevis 23017), a selected probiotics strain with strong mercury binding capacities, was applied to evaluate the efficiency against mercury toxicity in a mouse model. Histopathological results along with HE stains show that L. brevis 23017 protects the integrity of the small intestinal villus, which slows weight loss in response to Hg exposure. The qRT-PCR results demonstrate that L. brevis 23017 maintains a normal mucosal barrier via modulation of tight junction proteins. Importantly, the present study demonstrates that L. brevis 23017 effectively ameliorates injury of the small intestine by reducing intestinal inflammation and alleviating oxidative stress in animal models. Moreover, L. brevis 23017 blocks oxidative stress and inflammation through MAPK and NF-kappa B pathways, as shown by western blot. Conclusions: Together, these results reveal that L. brevis 23017 may have applications in the prevention and treatment of oral Hg exposure with fermented functional foods by protecting gut health in daily life.

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