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A high-fat diet increases body fat mass and up-regulates expression of genes related to adipogenesis and inflammation in a genetically lean pig

文献类型： 外文期刊

作者： Yang, Xue-fen 1 ; Qiu, Yue-qin 1 ; Wang, Li 1 ; Gao, Kai-guo 1 ; Jiang, Zong-yong 2 ;

作者机构： 1.Guangdong Acad Agr Sci, Lab Anim Nutr & Feed South China,Inst Anim Sci, Minist Agr,State Key Lab Livestock & Poultry Bree, Guangdong Key Lab Anim Breeding & Nutr,Guangdong, Guangzhou 510640, Guangdong, Peoples R China

2.Guangdong Acad Agr Sci, Lab Anim Nutr & Feed South China,Inst Anim Sci, Minist Agr,State Key Lab Livestock & Poultry Bree, Guangdong Key Lab Anim Br

关键词： Genetically lean pig; Diet-induced obesity; High-fat diet; Adiposity deposition; Microarray analysis; Inflammation

期刊名称：JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B （ 影响因子：3.066； 五年影响因子：3.057 ）

ISSN： 1673-1581

年卷期： 2018 年 19 卷 11 期

页码：

收录情况： SCI

摘要： Because of their physiological similarity to humans, pigs provide an excellent model for the study of obesity. This study evaluated diet-induced adiposity in genetically lean pigs and found that body weight and energy intake did not differ between controls and pigs fed the high-fat (HF) diet for three months. However, fat mass percentage, adipocyte size, concentrations of total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C), insulin, and leptin in plasma were significantly higher in HF pigs than in controls. The HF diet increased the expression in backfat tissue of genes responsible for cholesterol synthesis such as Insig-1 and Insig-2. Lipid metabolism-related genes including sterol regulatory element binding protein 1c (SREBP-1c), fatty acid synthase 1 (FASN1), diacylglycerol O-acyltransferase 2 (DGAT2), and fatty acid binding protein 4 (FABP4) were significantly up-regulated in backfat tissue, while the expression of proliferator-activated receptor-alpha (PPAR-alpha) and carnitine palmitoyl transferase 2 (CPT2), both involved in fatty acid oxidation, was reduced. In liver tissue, HF feeding significantly elevated the expression of SREBP-1c, FASN1, DGAT2, and hepatocyte nuclear factor-4 alpha (HNF-4 alpha) mRNAs. Microarray analysis further showed that the HF diet had a significant effect on the expression of 576 genes. Among these, 108 genes were related to 21 pathways, with 20 genes involved in adiposity deposition and 26 related to immune response. Our results suggest that an HF diet can induce genetically lean pigs into obesity with body fat mass expansion and adipose-related inflammation.

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