文献类型： 外文期刊
作者： Guo, Lijin 1 ; Huang, Weiling 1 ; Chen, Biao 1 ; Bekele, Endashaw Jebessa 1 ; Chen, Xiaolan 1 ; Cai, Bolin 1 ; Nie, Qi 1 ;
作者机构： 1.South China Agr Univ, Dept Anim Genet Breeding & Reprod, Coll Anim Sci, Guangzhou, Guangdong, Peoples R China
2.Minist Agr, Guangdong Prov Key Lab Agroanim Genom & Mol Breed, Guangzhou, Guangdong, Peoples R China
3.Minist Agr, Key Lab Chicken Genet, Guangzhou, Guangdong, Peoples R China
关键词： gga-mir-133a-3p; PRRX1; myoblast; proliferation; differentiation
期刊名称：FRONTIERS IN GENETICS （ 影响因子：4.599； 五年影响因子：4.888 ）
ISSN： 1664-8021
年卷期： 2018 年 9 卷
页码：
收录情况： SCI
摘要： Non-coding RNAs play a regulatory role in the growth and development of skeletal muscle. Our previous study suggested that gga-mir-133a-3p was a potential candidate for regulating myoblast proliferation and differentiation in skeletal muscle. The purpose of our study was to reveal the regulatory mechanism of gga-mir-133a-3p in the proliferation and differentiation of chicken myoblasts. Through the detection of cell proliferation activity, cell cycle progression and EdU, we found that gga-mir-133a-3p can significantly inhibit the proliferation of myoblasts. In the process of myogenic differentiation, gga-mir-133a-3p is up-regulated, while gga-mir-133a-3p can significantly promote the up-regulation of differentiation-related muscle-derived factors, indicating that gga-mir-133a-3p can promote the differentiation of myoblasts. Validation at the transcriptional level and protein level proved that gga-mir-133a-3p can inhibit the expression of PRRX1, and the dual-luciferase assay also showed their direct targeting relationship. Correspondingly, PRRX1 can significantly promote myoblast proliferation and inhibit myoblast differentiation. In our study, we confirmed that gga-mir-133a-3p participates in the regulation of proliferation and differentiation of myoblasts by targeting PRRX1.
- 相关文献
作者其他论文 更多>>
-
Exploring variances in meat quality between Qingyuan partridge chicken and Cobb broiler: Insights from combined multi-omics analysis
作者：Yang, Xin;Cai, Bolin;Zhang, Zhaofeng;Mo, Yu;Zhou, Zhen;Wu, Ruiquan;Kong, Shaofen;Cai, Danfeng;Zhang, Ruitong;Li, Zhenhui;Nie, Qinghua;Yang, Xin;Cai, Bolin;Zhang, Zhaofeng;Mo, Yu;Zhou, Zhen;Wu, Ruiquan;Kong, Shaofen;Cai, Danfeng;Li, Zhenhui;Nie, Qinghua
关键词：Qingyuan partridge chicken; Commercial broiler; Meat quality; Multi-omics analysis
-
EGR1 mRNA expression levels and polymorphisms are associated with slaughter performance in chickens
作者：Ye, Mao;Ye, Chutian;Guo, Lijin;Fan, Zhexia;Ma, Xuerong;Liu, Aijun;Liang, Weiming;Chen, Shuya;Fang, Cheng;Zhang, Xiquan;Luo, Qingbin;Ye, Mao;Chao, Xiaohuan;Ye, Chutian;Guo, Lijin;Fan, Zhexia;Ma, Xuerong;Liu, Aijun;Liang, Weiming;Chen, Shuya;Fang, Cheng;Zhang, Xiquan;Luo, Qingbin;Ye, Mao;Chao, Xiaohuan;Ye, Chutian;Guo, Lijin;Fan, Zhexia;Ma, Xuerong;Liu, Aijun;Liang, Weiming;Chen, Shuya;Fang, Cheng;Zhang, Xiquan;Luo, Qingbin;Ye, Mao;Chao, Xiaohuan;Ye, Chutian;Guo, Lijin;Fan, Zhexia;Ma, Xuerong;Liu, Aijun;Liang, Weiming;Chen, Shuya;Fang, Cheng;Zhang, Xiquan;Luo, Qingbin
关键词：Early growth response protein 1 ( EGR1 ); Polymorphism; Slaughter performance; Association analysis; Skeletal muscle
-
G-Quadruplexes in Gene Regulation and Cellular Function
作者：Guo, Lijin;Nie, Qinghua
关键词：diseases; function; G-quadruplex; structure
-
Skeletal muscle myopathies and cardiovascular diseases in poultry: challenges for meat production
作者：Bordbar, Farhad;Wadood, Armughan Ahmed;Nie, Qinghua;Guo, Wei
关键词：Poultry; muscle growth; meat quality; muscle myopathy; cardiomyopathy
-
Changes in gut microbiota affect DNA methylation levels and development of chicken muscle tissue
作者：Xu, Yibin;Huang, Yunpeng;Wei, Shenghua;Tian, Jinghong;Nie, Qinghua;Zhang, Dexiang;Xu, Yibin;Huang, Yunpeng;Wei, Shenghua;Tian, Jinghong;Nie, Qinghua;Zhang, Dexiang;Xu, Yibin;Huang, Yunpeng;Wei, Shenghua;Tian, Jinghong;Nie, Qinghua;Zhang, Dexiang;Xu, Yibin;Huang, Yunpeng;Wei, Shenghua;Tian, Jinghong;Nie, Qinghua;Zhang, Dexiang;Huang, Yulin;Zhang, Dexiang
关键词：Gut microbiome; Yellow-feathered chicken; Growth and development; DNA methylation
-
Improvement of the accuracy of breeding value prediction for egg production traits in Muscovy duck using low-coverage whole-genome sequence data
作者：Ye, Haoqiang;Liu, Xiaoqi;Bello, Semiu Folaniyi;Guo, Lijin;Fang, Xiang;Lin, Duo;Mo, Yu;Lei, Zhilin;Cai, Bolin;Nie, Qinghua;Ye, Haoqiang;Liu, Xiaoqi;Bello, Semiu Folaniyi;Guo, Lijin;Fang, Xiang;Lin, Duo;Mo, Yu;Lei, Zhilin;Cai, Bolin;Nie, Qinghua;Ye, Haoqiang;Liu, Xiaoqi;Bello, Semiu Folaniyi;Guo, Lijin;Fang, Xiang;Lin, Duo;Mo, Yu;Lei, Zhilin;Cai, Bolin;Nie, Qinghua;Ji, Congliang;Bello, Semiu Folaniyi
关键词：Muscovy duck; Low-coverage whole genome sequencing; Genomic prediction; Egg production traits; Linkage disequilibrium
-
Genetic regulation of gene expression across multiple tissues in chickens
作者：Guan, Dailu;Wang, Ying;Zhou, Huaijun;Bai, Zhonghao;Zhu, Di;Li, Houcheng;Buitenhuis, Albert Johannes;Sahana, Goutam;Lund, Mogens Sando;Fang, Lingzhao;Zhu, Xiaoning;Zhu, Di;Wang, Yuzhe;Hu, Xiaoxiang;Zhong, Conghao;Lan, Fangren;Li, Xiaochang;Sun, Congjiao;Yang, Ning;Zhong, Conghao;Lan, Fangren;Li, Xiaochang;Sun, Congjiao;Yang, Ning;Hou, Yali;Pan, Zhangyuan;Si, Wei;Diao, Shuqi;Gao, Yahui;Teng, Jinyan;Xu, Zhiting;Lin, Qing;Li, Zhenhui;Nie, Qinghua;Zhang, Xiquan;Zhang, Zhe;Yao, Yuelin;Yao, Yuelin;Zhao, Bingru;Gao, Yahui;Liu, George E.;Gao, Yahui;Zou, Dong;Wang, Ruizhen;Xu, Tianyi;Zhang, Zhang;Zou, Dong;Wang, Ruizhen;Xu, Tianyi;Zhang, Zhang;Wang, Ruizhen;Zhang, Zhang;Yin, Hongwei;Shi, Shourong;Shao, Dan;Degalez, Fabien;Lagarrigue, Sandrine;Wang, Mingshan;Peng, Minsheng;Wang, Mingshan;Peng, Minsheng;Rocha, Dominique;Charles, Mathieu;Smith, Jacqueline;Watson, Kellie;Warren, Wesley;Frantz, Laurent;Frantz, Laurent;Larson, Greger;Lamont, Susan J.;Si, Wei;Zhao, Xin;Li, Bingjie;Zhang, Haihan;Luo, Chenglong;Shu, Dingming;Qu, Hao;Luo, Wei;Li, Zhenhui;Nie, Qinghua;Zhang, Xiquan;Li, Zhenhui;Nie, Qinghua;Zhang, Xiquan;Xiang, Ruidong;Xiang, Ruidong;Xiang, Ruidong;Liu, Shuli;Cheng, Hans
关键词：
