文献类型： 外文期刊
作者： Liao, Rongrong 1 ; Lin, Yuexia 1 ; Zhu, Lihui 1 ;
作者机构： 1.Shanghai Acad Agr Sci, Inst Anim Sci & Vet Med, 2901 Beidi Rd, Shanghai, Peoples R China
关键词： MiRNA; Pathway; Therapeutics; Clinical trials
期刊名称：MOLECULAR BIOLOGY REPORTS （ 影响因子：2.316； 五年影响因子：2.357 ）
ISSN： 0301-4851
年卷期： 2018 年 45 卷 6 期
页码：
收录情况： SCI
摘要： Multidrug resistance (MDR) is still a major reason for therapeutic failure in cancers. The mechanisms underlying MDR are multifactorial and are not fully understood. miRNAs are evolutionarily conserved non-coding RNAs that function as key post-transcriptional regulators of gene expression. Emerging evidence indicates a vital role of miRNAs in the resistance to cancer treatments and suggests their potential for cancer therapy, as they can modulate multiple mechanisms link to the development of MDR. This review summarizes the recent findings on the role of miRNAs in MDR, and highlights the molecular targets and mechanisms of miRNA regulated pathways in MDR. Finally, the challenges and prospects of miRNA-targeted therapies for reversing drug resistance are reviewed.
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