文献类型： 外文期刊
作者： Yang, Hue 1 ; Xiang, Yun 2 ; Robinson, Kelsy 3 ; Wang, Junjun 4 ; Zhang, Guolong 3 ; Zhao, Jiangchao 6 ; Xiao, Yingpin 1 ;
作者机构： 1.Zhejiang Acad Agr Sci, Inst Qual & Stand Agroprod, Hangzhou, Zhejiang, Peoples R China
2.Jinhua Acad Agr Sci, Inst Anim Husb & Vet Med, Jinhua, Peoples R China
3.Oklahoma State Univ, Dept Anim & Food Sci, Stillwater, OK 74078 USA
4.China Agr Univ, Belling Adv Innovat Ctr Food Nutr & Human Hlth, Beijing, Peoples R China
5.China Agr Univ, State Key Lab Anim Nutr, Beijing, Peoples R China
6.Univ Arkansas, Dept Anim Sci, Div Agr, Fayetteville, AR 72701 USA
关键词： microbiota; fecal microbiota transplantation; fat metabolism; adipogenesis; obesity; pigs
期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：5.64； 五年影响因子：6.32 ）
ISSN： 1664-302X
年卷期： 2018 年 9 卷
页码：
收录情况： SCI
摘要： Different breeds of pigs vary greatly in their propensity for adiposity. Gut microbiota is known to play an important role in modulating host physiology including fat metabolism. However, the relative contribution of gut microbiota to lipogenic characteristics of pigs remains elusive. In this study, we transplanted fecal microbiota of adult Jinhua and Landrace pigs, two breeds of pigs with distinct lipogenic phenotypes, to antibiotic-treated mice. Our results indicated that, 4 weeks after fecal transplantation, the mice receiving Jinhua pigs' "obese" microbiota (JM) exhibited a different intestinal bacterial community structure from those receiving Landrace pigs' "lean" microbiota (LM). Notably, an elevated ratio of Firmicutes to Bacteroidetes and a significant diminishment of Akkermansia were observed in JM mice relative to LM mice. Importantly, mouse recipients resembled their respective porcine donors in many of the lipogenic characteristics. Similar to Jinhua pig donors, JM mice had elevated lipid and triglyceride levels and the lipoprotein lipase activity in the liver. Enhanced expression of multiple key lipogenic genes and reduced angiopoietin-like 4 (Angptl4) mRNA expression were also observed in JM mice, relative to those in LM mice. These results collectively suggested that gut microbiota of Jinhua pigs is more capable of enhancing lipogenesis than that of Landrace pigs. Transferability of the lipogenic phenotype across species further indicated that gut microbiota plays a major role in contributing to adiposity in pigs. Manipulation of intestinal microbiota will, therefore, have a profound impact on altering host metabolism and adipogenesis, with an important implication in the treatment of human overweight and obesity.
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