Effects of curcumin on performance, antioxidation, intestinal barrier and mitochondrial function in ducks fed corn contaminated with ochratoxin A
文献类型： 外文期刊
作者： Ruan, D. 1 ; Wang, W. C. 1 ; Lin, C. X. 2 ; Fouad, A. M. 2 ; Chen, W. 2 ; Xia, W. G. 2 ; Wang, S. 2 ; Luo, X. 2 ; Zhang, W. 1 ;
作者机构： 1.South China Agr Univ, Coll Anim Sci, Guangzhou 510642, Guangdong, Peoples R China
2.Guangdong Acad Agr Sci, Inst Anim Sci, Guangzhou 510640, Guangdong, Peoples R China
3.Cairo Univ, Fac Agr, Dept Anim Prod, Giza 12613, Egypt
4.Guangdong Acad Agr Sci, Agrobiol Gene Res Ctr, Guangzhou 510640, Guangdong, Peoples R China
5.Guangdong Acad Agr Sci, Inst Anim Sci, 1 Dafeng First St,Wushan Rd, Guangzhou 510640, Guangdong, Peoples R China
关键词： curcumin; ochratoxin A; enterotoxicity; intestinal function; ducks
期刊名称：ANIMAL （ 影响因子：3.24； 五年影响因子：3.223 ）
ISSN： 1751-7311
年卷期： 2019 年 13 卷 1 期
页码：
收录情况： SCI
摘要： Curcumin has been attributed with antioxidant, anti-inflammatory, antibacterial activities, and has shown highly protective effects against enteropathogenic bacteria and mycotoxins. Ochratoxin A (OTA) is one of the major intestinal pathogenic mycotoxins. The possible effect of curcumin on the alleviation of enterotoxicity induced by OTA is unknown. The effects of dietary curcumin supplementation on OTA-induced oxidative stress, intestinal barrier and mitochondrial dysfunctions were examined in young ducks. A total of 540 mixed-sex 1-day-old White Pekin ducklings with initial BW (43.4 +/- 0.1 g) were randomly assigned into controls (fed only the basal diet), a group fed an OTA-contaminated diet (2 mg/kg feed), and a group fed the same OTA-contaminated feed plus 400 mg/kg of curcumin. Each treatment consisted of six replicates, each containing 30 ducklings and treatment lasted for 21 days. There was a significant decrease in average daily gain (ADG) and increased feed : gain caused by OTA (P < 0.05); curcumin co-treatment prevented the decrease in BW and ADG compared with the OTA group (P < 0.05). Histopathological and ultrastructural examination showed clear signs of enterotoxicity caused by OTA, but these changes were largely prevented by curcumin supplementation. Curcumin decreased the concentrations of interleukin-1 beta, tumor necrosis factor-alpha and malondialdehyde, and increased the activity of glutathione peroxidase induced by OTA in the jejunal mucosa of ducks (P < 0.05). Additionally, curcumin increased jejunal mucosa occludin and tight junction protein 1 mRNA and protein levels, and decreased those of rho-associated protein kinase 1 (P < 0.05). Notably, curcumin inhibited the increased expression of apoptosis-related genes, and downregulated mitochondrial transcription factors A, B1 and B2 caused by OTA without any effects on RNA polymerase mitochondrial (P < 0.05). These results indicated that curcumin could protect ducks from OTA-induced impairment of intestinal barrier function and mitochondrial integrity.
- 相关文献
作者其他论文 更多>>
-
Dietary isoleucine supplementation enhances growth performance, modulates the expression of genes related to amino acid transporters and protein metabolism, and gut microbiota in yellow-feathered chickens
作者：Ruan, D.;Fan, Q. L.;Zhang, S.;Lin, X. J.;Zheng, C. T.;Jiang, Z. Y.;Jiang, S. Q.;EI-Senousey, H. K.;Fouadt, A. M.;Yan, S. J.;Yan, S. J.
关键词：isoleucine; yellow -feathered chickens; amino acid transporters; protein metabolism; gut microbiota
-
Dietary non-phytate phosphorus requirements for optimal productive and reproductive performance, and egg and tibial quality in egg-type duck breeders
作者：Xia, W. G.;Abouelezz, K.;Huang, X. B.;Li, K. C.;Chen, W.;Wang, S.;Zhang, Y. N.;Jin, C. L.;Zheng, C. T.;Abouelezz, K.;Azzam, M. M. M.
关键词：Duck breeder; Egg incubation; Egg production; Inorganic phosphorus; Tibial characteristics
-
Dietary vitamin D3 requirement of magang goslings from 1-21 days of age
作者：Wang, H.;Wang, X. Y.;Zhan, Y. C.;Wang, W. C.;Yang, L.;Zhu, Y. W.;Peng, B.;Zhang, H. Q.
关键词：Vitamin D-3 requirement; Geese; Calcium-phosphorus metabolism; Tibia development
-
Comparative effects of inorganic and organic manganese supplementation on productive performance, egg quality, tibial characteristics, serum biochemical indices, and fecal Mn excretion of laying ducks
作者：Zhang, Y. N.;Wang, S.;Huang, X. B.;Li, K. C.;Ruan, D.;Xia, W. G.;Wang, S. L.;Chen, W.;Zheng, C. T.
关键词：Manganese; Productive performance; Egg quality; Tibial characteristics; Fecal Mn excretion; Laying duck
-
Change of zinc mobilization and gene expression of key zinc transport proteins between the yolk sac membrane and liver of duck embryonic developing
作者：Bai, S. P.;Gao, W.;Yuan, T.;He, L. J.;Huang, L.;Wang, W. C.;Yang, L.;Zhu, Y. W.;Bai, S. P.;Ma, X. Y.;Wei, S.;Liu, C.
关键词：zinc mobilization; developmental change; zinc transport protein; duck embryo
-
Effects of maternal and progeny dietary selenium supplementation on growth performance and antioxidant capacity in ducklings
作者：Xia, W. G.;Chen, W.;Abouelezz, K. F. M.;Li, K. C.;Huang, X. B.;Wang, S.;Ruan, D.;Zhang, Y. N.;Zheng, C. T.;Huang, Z. H.;Fouad, A. M.;Abouelezz, K. F. M.
关键词：selenium; duckling; antioxidative biochemistry; muscle development
-
Effects of dietary inclusion of cassava starch-extraction-residue meal on egg production, egg quality, oxidative status, and yolk fatty acid profile in laying ducks
作者：Abouelezz, K. F. M.;Wang, S.;Xia, W. G.;Chen, W.;Zhang, Y. N.;Zheng, C. T.;Abouelezz, K. F. M.;Elokil, A. A.;Wang, S. L.;Li, K. C.;Huang, X. B.
关键词：cassava starch-extraction-residue meal; laying duck; productive performance; yolk fatty acids; lipid metabolism
