Developmental toxicity of kresoxim-methyl during zebrafish (Danio rerio) larval development
文献类型： 外文期刊
作者： Jiang, Jinhua 1 ; Lv, Lu 1 ; Wu, Shenggan 1 ; An, Xuehua 1 ; Wang, Feidi 1 ; Liu, Xinju 1 ; Zhao, Xueping 1 ;
作者机构： 1.Zhejiang Acad Agr Sci, Inst Qual & Stand Agroprod, State Key Lab Breeding Base Zhejiang Sustainable, Hangzhou 310021, Zhejiang, Peoples R China
关键词： Kresoxim-methyl; Zebrafish; Oxidative stress; Apoptosis; Endocrine disruption
期刊名称：CHEMOSPHERE （ 影响因子：7.086； 五年影响因子：6.956 ）
ISSN： 0045-6535
年卷期： 2019 年 219 卷
页码：
收录情况： SCI
摘要： Kresoxim-methyl (KM) is a broad spectrum strobilurin fungicide that has been used widely on crops around the world. In the present study, we aimed to investigate the toxic effects of KM using various sublethal endpoints during zebrafish (Danio rerio) larval development. Results showed that the LC50 values of KM to zebrafish at multiple life stages (embryo, larvae, juvenile and adult) were 0.340, 0.224, 0.328 and 0.436 mg/L, respectively. The transcription patterns of 45 genes involved in hypothalamic-pituitary-thyroid/gonadal (HPT/HPG) axis, oxidative stress and apoptosis revealed KM could affect zebrafish larval development at multiple pathways. The activities of aromatase, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), caspase 3 (Cas3) and caspase 9 (Cas9), and the levels of estradiol (E-2), vitellogenin (VTG), thyroid hormones (T-3 and T-4), reactive oxygen species (ROS) and ATP after embryos exposed to KM for 3 d, 6 d and 10 d were correlated well with the transcription of the corresponding molecules involved in these pathways. In addition to providing the first description of the toxic effects induced by KM during larval development, the results of present study also provided the potential mechanisms of KM on multi-level biomarker responses in larval zebrafish. (C) 2018 Published by Elsevier Ltd.
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