文献类型： 外文期刊
作者： Zhang, Yong 1 ; Qi, Zhimin 1 ; Liu, Yan 1 ; He, Wenqi 3 ; Yang, Cheng 4 ; Wang, Quan 4 ; Dong, Jing 5 ; Deng, Xuming 1 ;
作者机构： 1.Jilin Univ, Hosp 1, Changchun, Peoples R China
2.Jilin Univ, Inst Infect & Immun, Changchun, Peoples R China
3.Jilin Univ, Inst Zoonosis, Coll Vet Med, Key Lab Zoonosis,Minist Educ, Changchun, Peoples R China
4.Tianjin Int Joint Acad Biotechnol & Med, High Throughput Mol Drug Discovery Ctr, Tianjin, Peoples R China
5.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Wuhan, Peoples R China
关键词： Shiga-like toxin; Escherichia coli (STEC) O157: H7; baicalin; infection; antibiotics
期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：5.64； 五年影响因子：6.32 ）
ISSN： 1664-302X
年卷期： 2017 年 8 卷
页码：
收录情况： SCI
摘要： Shiga-like toxin-producing Escherichia coli (STEC) O157:H7 poses grave challenges to public health by its ability to cause severe colonic diseases and renal failure in both human and animals. Shiga-like toxins are the major pathogenic factor for some highly virulent E. coli expecially Shiga-like toxin 2. Conventional treatments such as antibiotics can facilitate the release of the toxin thus potentially exacerbate the diseases. Small molecule inhibitors and antibodies capable of neutralizing the toxins are the two major venues for the development of therapeutics against enterohemorrhagic serotype E. coli infection. While promising and potentially effective at clinical settings, these approaches need to overcome obstacles such as the limited routes of administration, responses from the host immune system, which are known to differ greatly among individuals. Our previous studies demonstrate that Baicalin (BAI), a flavonoid compound isolated from Scutellaria baicalensis protects against rStx2-induced cell cytotoxicity and also protects mice from lethal rStx2 challenges by inducing Stx2 to form inactive oligomers. In this manuscript, we present some exciting work showing that baicalin is an effective agent for therapeutic treatment of STEC O157: H7 infection.
- 相关文献
作者其他论文 更多>>
-
Fraxetin Targeting to Sortase A Decreases the Pathogenicity of Streptococcus agalactiae to Nile Tilapia
作者：Dong, Jing;Zhang, Yuze;Yang, Qiuhong;Liu, Yongtao;Zhou, Shun;Ai, Xiaohui;Zhang, Yuze
关键词：Streptococcus agalactiae; sortase A; fraxetin; tilapia; anti-virulence
-
Spatiotemporal Variation and Predictors of the Purpleback Flying Squid (Sthenoteuthis oualaniensis) Distribution Surrounding the Xisha and Zhongsha Islands during a Fishing Moratorium
作者：Wang, Liangming;Yang, Changping;Shan, Binbin;Liu, Yan;Sun, Dianrong;Wang, Liangming;Yang, Changping;Shan, Binbin;Liu, Yan;Sun, Dianrong;Wang, Liangming;Zou, Jianwei;Guo, Tao
关键词：purpleback flying squid; Xisha and Zhongsha islands; fishing ground; environmental factors
-
Effects of Three Sources of Astaxanthin on the Growth, Coloration, and Antioxidant Capacity of Rainbow Trout (Oncorhynchus mykiss) during Long-Term Feeding
作者：Wang, Lei;Wu, Xugan;Long, Xiaowen;Li, Yaopeng;Zhang, Yong;Sun, Weihong;Wu, Xugan
关键词：astaxanthin; Oncorhynchus mykiss; growth performance; coloration; antioxidant capacity
-
Response of the spatiotemporal distribution of crimson seabream ( Paerargyrops edita ) to La Nin a event in the northern Beibu Gulf, South China Sea
作者：Wang, Liangming;Liu, Yan;Yang, Changping;Shan, Binbin;Sun, Dianrong;Qiu, Yongsong;Wang, Liangming;Liu, Yan;Yang, Changping;Shan, Binbin;Sun, Dianrong;Qiu, Yongsong
关键词：Northern Beibu Gulf; Crimson seabream; Gradient forest analysis; Generalized additive model; LaNina event
-
Early ontogenesis from embryo to juvenile in Senegalese sole Solea senegalensis under laboratory conditions
作者：Liu, Liming;Wang, Jiulong;Liu, Yan;Xu, Wengang;Zeng, Jun;Mei, Weiping;Zeng, Jun;Mei, Weiping;Wu, Yanqin;Wang, Chengwu;Xu, Wengang
关键词：embryonic development; flatfish; growth; hatching; juvenile; larval
-
Efficacy and safety assessment of triclabendazole for treating Gyrodactylus infections in goldfish
作者：Zhou, Shun;Dong, Jing;Liu, Yongtao;Yang, Qiuhong;Zhang, Lang;Ai, Xiaohui;Chen, Shengao;Xia, Liwei
关键词：Triclabendazole; Anthelmintic activity; Safety; Gyrodactylids
-
Dissolved oxygen prediction using regularized extreme learning machine with clustering mechanism in a black bass aquaculture pond
作者：Shi, Pei;Yuan, Limin;Wang, Quan;Zhang, Yonghong;Kuang, Liang;Kuang, Liang;Li, Guanghui;Yuan, Yongming;Huang, Guangyan
关键词：Dissolved oxygen; Aquaculture; IoT monitoring system; Prediction model; Regularized extreme learning machine
