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Cross-regulatory Circuit Between AHR and Microbiota

文献类型： 外文期刊

作者： Ji, Jian 1 ; Qu, Hao 1 ;

作者机构： 1.Guangdong Acad Agr Sci, State Key Lab Livestock & Poultry Breeding, Guangdong Key Lab Anim Breeding & Nutr, Inst Anim Sci, Guangzhou, Guangdong, Peoples R China

关键词： Aryl hydrocarbon receptor (AHR); ligand; xenobiotics; microbiota; cross-regulatory; homeostasis

期刊名称：CURRENT DRUG METABOLISM （ 影响因子：3.731； 五年影响因子：3.601 ）

ISSN： 1389-2002

年卷期： 2019 年 20 卷 1 期

页码：

收录情况： SCI

摘要： Background: The gut microbes have a close symbiotic relationship with their host. Interactions between host and the microbiota affect the nutritional, immunological, and physiological status of the host. The Aryl Hydrocarbon Receptor (AHR) is a ligand activated transcription factor that mediates the toxicity of xenobiotics. Recently, the relationship between the gut microbiota and AHR has attracted the attention of many researchers. Methods: We undertook a structured search of bibliographic databases for peer-reviewed research literature. Results: We found and reviewed 49 peer-reviewed papers dealing with the major aspects related to the crosstalk between AHR and microbiota. The AHR influences the intestinal microbiota population and mediates host-microbe homeostasis. Interestingly, the gut microbiota also produces ligands of AHR from bacterial metabolism and thereby activates the AHR signaling pathway. Concusion: This review presents current knowledge of the cross-regulatory circuit between the AHR and intestinal microbiota. The findings of this review confirm the importance of AHR-microbiota interactions in health and disease.

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