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Changes in antibiotic residues and the gut microbiota during ciprofloxacin administration throughout Silkie chicken development

文献类型： 外文期刊

作者： Yuan, Yushan 1 ; Chen, Peng 1 ; Li, Ying 1 ; Cheng, Jiaheng 1 ; Yan, Xia 1 ; Luo, Chenglong 1 ; Shu, Dingming 1 ; Qu, Hao 1 ; Ji, Jian 1 ;

作者机构： 1.Guangdong Acad Agr Sci, Inst Anim Sci, State Key Lab Livestock & Poultry Breeding, Guangdong Key Lab Anim Breeding & Nutr, Guangzhou, Peoples R China

关键词： ciprofloxacin; pharmacokinetics; gut microbiota; metabolism; Silkie chicken

期刊名称：POULTRY SCIENCE （ 影响因子：4.014； 五年影响因子：4.192 ）

ISSN： 0032-5791

年卷期： 2023 年 102 卷 1 期

页码：

收录情况： SCI

摘要： The use of antibiotics leads to antibiotic residues in livestock and poultry products, adversely affect-ing human health. Ciprofloxacin (CFX) is a broad-spec-trum antibiotic shared between animals and humans that is useful in treatments besides infections. However, changes in the gut microbiota caused by CFX and the possible link with the elimination of CFX residues have not been inves-tigated. Herein, we used the Silkie chicken model to study the changes in the gut microbiota during the entire CFX-metabolic repertoire. We detected CFX residues in differ-ent tissues and showed that the elimination time of CFX from different tissues was dissimilar (liver > kidney > chest muscle > skin). Analysis of liver and kidney injury bio-markers and plasma antioxidant indices indicated slight hepatotoxicity and nephrotoxicity in the Silkie chickens. Importantly, the changes in the gut microbial community predominantly occurred early in the metabolic process. Correlation analysis revealed that the particular bacterial microbiota were associated with the pharmacokinetics of CFX in different Silkie chicken tissues (e.g., aerobic bacte-ria, including Escherichia and Coprococcus, and anaerobic bacteria, including Fusobacterium, Ruminococcus, Bifido-bacterium, and Eubacterium). Collectively, certain micro -biota may boost antibiotic metabolism and participate in restoring the microbial consortia after CFX is metabolized. Therefore, regulating the core intestinal microbiota may reduce foodborne antibiotics and accelerate the develop-ment of drug resistance.

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