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Forsythiaside attenuates Escherichia coli lipopolysaccharide-induced liver acute inflammatory response in chicken

文献类型： 外文期刊

作者： Bai, Jingwen 1 ; Wang, Xiaoting 2 ; Hao, Meiqi 2 ; Li, He 2 ; Cheng, Guangdong 3 ; Liu, Di 4 ; Yang, Yu 1 ; Li, Yanhua 2 ;

作者机构： 1.Northeast Agr Univ, Coll Sci, Harbin, Heilongjiang, Peoples R China

2.Northeast Agr Univ, Coll Vet Med, Harbin, Heilongjiang, Peoples R China

3.Jiamusi Univ, Coll Life Sci, Jiamusi, Peoples R China

4.Heilongjiang Acad Agr Sci, Harbin, Heilongjiang, Peoples R China

关键词： chicken; forsythiaside; inflammation; lipopolysaccharide; pro-inflammatory cytokine

期刊名称：EUROPEAN JOURNAL OF INFLAMMATION （ 影响因子：0.466； 五年影响因子：0.599 ）

ISSN： 2058-7392

年卷期： 2019 年 17 卷

页码：

收录情况： SCI

摘要： This study investigated the effects of forsythiaside on the acute inflammatory response induced by Escherichia coli lipopolysaccharide (LPS) in liver of broiler chickens. Fifteen-day-old chickens were randomly assigned to three groups (n = 20 for each group, orally treated with 0, 30, or 60 mg/kg BW of forsythiaside) for 7 days. At 21 days of age, the chickens were intravenously injected with either LPS (200 mu g/kg BW) or sterile saline (200 mu g/kg BW, control group). All the chickens were humanely euthanized by cervical dislocation 2 h after the LPS injection. The results showed that the injection of LPS induced some indexes, including total proteins, nitric oxide (NO), interleukin-1beta (IL-1 beta), interleukin-6 (IL-6), and interleukin-17 (IL-17) production (P < 0.05) and increased the mRNA expression of LPS-induced tumor necrosis factor-alpha (LITAF), IL-1 beta, IL-17, IL-6, and inducible nitric oxide synthase (iNOS) (P < 0.05). Forsythiaside supplementation alleviated the LPS-induced inflammatory response by inhibiting the production of total proteins, NO, LITAF, IL-1 beta, IL-17, and IL-6 and down-regulating the mRNA expression of pro-inflammatory cytokines and iNOS. In conclusion, forsythiaside is a potential treatment for LPS-induced liver acute inflammation in chicken.

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