您好，欢迎访问湖北省农业科学院 机构知识库！
湖北省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Synthesis and biological evaluation of marine alkaloid-oriented beta-carboline analogues

文献类型： 外文期刊

作者： Xu, Tingting 2 ; Shi, Liqiao 1 ; Zhang, Yani 1 ; Wang, Kaimei 1 ; Yang, Ziwen 1 ; Ke, Shaoyong 1 ;

作者机构： 1.Hubei Acad Agr Sci, Hubei Biopesticide Engn Res Ctr, Natl Biopesticide Engn Res Ctr, Wuhan 430064, Hubei, Peoples R China

2.Wuhan Univ, Coll Life Sci, Wuhan 430072, Hubei, Peoples R China

关键词： Marine alkaloid; Pityriacitrin; Analogues; Synthesis; Biological evaluation; SARs

期刊名称：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY （ 影响因子：6.514； 五年影响因子：6.099 ）

ISSN： 0223-5234

年卷期： 2019 年 168 卷

页码：

收录情况： SCI

摘要： Pityriacitrin is a marine alkaloid with typical beta-carboline scaffold, and which has been proven to exhibit diverse biological functions. During the course of our research for highly active compounds from natural products, the pityriacitrin have also been isolated and identified from a Chinese Burkholderia sp. NBF227. So, in order to explore the potential functional molecules, a series of beta-carboline analogues derived from pityriacitrin were designed and synthesized, and their in vitro cytotoxic activities against SGC-7901, A875, HepG2, and MARC145 cell lines were evaluated. The results demonstrated that some of these beta-carboline derivatives exhibited moderate to good cytotoxic activities, especially, compound 9o with a special sulfonyl group presented the highest inhibitory activities against all tested cell lines with the IC50 values of 6.82 +/- 0.98, 8.43 +/- 1.93, 7.69 +/- 2.17, 7.19 +/- 1.43 mu M, respectively, which might be used as lead compound for discovery of novel cytotoxic agents. (C) 2019 Elsevier Masson SAS. All rights reserved.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：湖北省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台