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Unlocking the neuroprotective secrets of natural products: a focus on the gut-brain axis

文献类型： 外文期刊

作者： Yang, Xiliang 1 ; Hu, Die 1 ; Cheng, Ruoyan 1 ; Bao, Qianqian 1 ; Jiang, Huan 1 ; Zhao, Binjie 1 ; Zhang, Yani 2 ;

作者机构： 1.Wuhan Univ Sci & Technol, Wuhan Asia Gen Hosp, Wuhan Wuchang Hosp, Inst Pharmaceut Proc,Inst Infect Immunol & Tumor M, Wuhan, Peoples R China

2.Hubei Acad Agr Sci, Hubei Biopesticide Engn Res Ctr, 8 Nanhu Ave, Wuhan 430064, Peoples R China

关键词： Natural products; Chinese medicine prescriptions; Gut-brain axis; Neuroprotective activity; Neurodegenerative disease

期刊名称：PHYTOCHEMISTRY REVIEWS （ 影响因子：7.6； 五年影响因子：9.0 ）

ISSN： 1568-7767

年卷期： 2025 年

页码：

收录情况： SCI

摘要： Traditional Chinese medicine has a history of thousands of years with a profound understanding and treatment of nervous system diseases. Natural products with neuroprotective activity have become potential neuroprotective agents. This review summarized the natural products and Chinese medicine prescriptions frequently used for treating neurological disorders, discussed the relationship between their regulatory effect and gut-brain axis, in order to provide scientific basis for clinical application. 81 compounds and 10 Chinese medicine prescriptions were analyzed for their significant neuroprotective activities, which are mediated through the regulation of the gut-brain axis. These compounds were meticulously classified based on their chemical structures, encompassing flavonoids, terpenoids, phenylpropanoids, phenolics, alkaloids, and carbohydrates. Notably, terpenoids constituted the largest share of these compounds. The pharmacological potential of these compounds was predominantly characterized by their anti-depressive (38.4%), anti-Alzheimer's disease (20.0%), anti-cognitive impairment (13.6%), and anti-Parkinson's disease activity (7.2%). The underlying mechanisms to treat neurological disorders by mediating the gut-brain axis are mainly through inhibiting nervous system inflammation, A beta aggregation, neuronal damage and synaptic dysfunction, improving neurotransmitter system dysfunction, repairing intestinal mucosa and blood-brain barrier, regulating metabolism, immunity, and intestinal flora homeostasis. The Chinese natural medicines and prescriptions show promise in treating a range of neurological disorders, particularly in the treatment of depression, Alzheimer's disease, cognitive impairment, and Parkinson's disease by balancing the gut microbiome, which not only provide new insights into the complex mechanisms of action of these medicines but also hold the potential for developing innovative therapeutic strategies.

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