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Antiviral Activity of Benzoheterocyclic Compounds from Soil-Derived Streptomyces jiujiangensis NBERC-24992

文献类型： 外文期刊

作者： Liu, Manli 1 ; Ren, Mengyao 2 ; Zhang, Yani 1 ; Wan, Zhongyi 1 ; Wang, Yueyin 1 ; Wu, Zhaoyuan 1 ; Wang, Kaimei 1 ; Fang, Wei 1 ; Yang, Xiliang 2 ;

作者机构： 1.Hubei Acad Agr Sci, Hubei Biopesticide Engn Res Ctr, 8 Nanhu Ave, Wuhan 430064, Peoples R China

2.Wuhan Univ Sci & Technol, Inst Infect Immunol & Tumor Microenvironm, Inst Pharmaceut Proc, Sch Med,Dept Pharm,Hubei Prov Key Lab Occupat Haza, 2 Huangjiahu East Rd, Wuhan 430081, Peoples R China

关键词： heterocyclic; virantmycin; PRV; Streptomyces; antiviral activity

期刊名称：MOLECULES （ 影响因子：4.6； 五年影响因子：4.9 ）

ISSN：

年卷期： 2023 年 28 卷 2 期

页码：

收录情况： SCI

摘要： Pseudorabies virus (PRV) is a pathogen that causes Aujeszky's disease (AD) in animals, leading to huge economic losses to swine farms. In order to discover anti-PRV compounds, we studied the extracts of the strain Streptomyces jiujiangensis NBERC-24992, which showed significant anti-PRV activity. Eight benzoheterocyclic secondary metabolites, including three new compounds (1-3, virantmycins D-G) and five known compounds (4-8, virantmycin, A-503451 D, A-503451 D acetylate, A-503451 A, and A-503451 B), were isolated from the broth of NBERC-24992. The structures of the new compounds were identified by using extensive spectroscopic data, including mass spectrometry (MS), nuclear magnetic resonance (NMR), and electronic circular dichroism (ECD). Compound 1 was found to be a novel heterocyclic compound with a tricyclic skeleton from natural product. All compounds were tested for antiviral activity, and 4 (virantmycin) showed an excellent effect against PRV and was better than ribavirin and acyclovir. Our study revealed that chlorine atom and tetrahydroquinoline skeleton were important active moiety for antiviral activity. Virantmycin could be a suitable leading compound for an antiviral drug against PRV.

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