Napyradiomycin A4 and Its Relate Compounds, a New Anti-PRV Agent and Their Antibacterial Activities, from Streptomyces kebangsaanensis WS-68302
文献类型： 外文期刊
作者： Zhang, Yani 1 ; Fang, Wei 1 ; Wang, Kaimei 1 ; Zhang, Zhigang 1 ; Wu, Zhaoyuan 1 ; Shi, Liqiao 1 ; Liu, Fang 1 ; Wan, Zhongyi 1 ; Liu, Manli 1 ;
作者机构： 1.Hubei Acad Agr Sci, Hubei Biopesticide Engn Res Ctr, 8 Nanhu Ave, Wuhan 430064, Peoples R China
关键词： napyradiomycins; anti-PRV; antibacterial; Streptomyces kebangsaanensis WS-68302
期刊名称：MOLECULES （ 影响因子：4.6； 五年影响因子：4.9 ）
ISSN：
年卷期： 2023 年 28 卷 2 期
页码：
收录情况： SCI
摘要： Two new napyradiomycins derivatives, napyradiomycin A4 (1) and A80915 H (2), along with five known ones, were isolated from the ethyl acetate extract of fermentation culture of Streptomyces kebangsaanensis WS-68302. Their structures were elucidated by extensive spectroscopic analysis, including HR-MS, 1D and 2D NMR, CD spectrum, as well as comparison with literature data. Compound 1 exhibited significant antiviral activity against PRV (Pseudorabies virus) with an IC50 value of 2.056 mu M and therapeutic ratio at 14.98, suggesting that it might have potential for development of an antiviral agent. Moreover, compound 1 displayed the strongest inhibition against PRV protein among the tested napyradiomycins in the indirect immunofuorescence assay. Compounds 3 and 4 showed higher activities against swine pathogenic Streptococcus suis than the positive control penicillin G sodium salt, with MIC values of 3.125 and 6.25 mu g/mL, respectively. Compounds 1 and 3-6 exhibited moderate antibacterial activity against the swine pathogenic Erysipelothrix rhusiopathiae, with MIC values ranging from 25 to 50 mu g/mL.
- 相关文献
作者其他论文 更多>>
-
Genomic and Comparative Transcriptomic Analyses Reveal Key Genes Associated with the Biosynthesis Regulation of Okaramine B in Penicillium daleae NBP-49626
作者：Wang, Yueying;Chen, Ling;Fang, Wei;Zeng, Zhen;Wu, Zhaoyuan;Liu, Fang;Liu, Xiaoyan;Gong, Yan;Zhu, Lei;Wang, Kaimei
关键词：Okaramine B; yield improvement; Penicillium daleae; complete genome; transcriptome; novel regulators; tryptophan metabolism
-
Discovery of structural diversity guided steroidal thiazolidin-4-one derivatives as potential cytotoxic agents targeting CDK1
作者：Yang, Fei;Min, Yong;Li, Kui;Yang, Ziwen;Wang, Kaimei;Gong, Yan;Liu, Manli;Ke, Shaoyong;Yang, Fei;Yang, Ziwen;Liu, Changli
关键词：Steroidal thiazolidin-4-ones; Structural diversity; Antiproliferative activity; Enzyme inhibitors; Molecular docking
-
A Study on the Efficient Preparation of α-Ketoglutarate with L-Glutamate Oxidase
作者：Niu, Shuhui;Liu, Fang;Rao, Ben;Wang, Yueying;Niu, Shuhui;Wang, Yaping
关键词：alpha-ketoglutaric acid (alpha-KG); L-glutamate oxidase; catalase; whole-cell catalysis
-
Substituted pyrazole derivatives as potential fungicidal agents
作者：Huang, Daye;Liu, Fang;Wen, Shaohua;Wang, Yueying;Fang, Wei;Zhang, Zhigang;Ke, Shaoyong
关键词：Pyrazole carboxamide; Hydrazone; Plant disease; Fungicidal activity
-
High-Quality Genome and Annotation Resource of Orange Pink Rot Pathogen Trichothecium roseum Strain YXFP-22015 Isolated from Hubei, China
作者：Zhu, Lei;Wu, Zhaoyuan;Fang, Wei;Wang, Yueying
关键词：annotation; fungi; high-quality genome; pink rot disease; RNA-seq; Trichothecium roseum
-
Bioactive Polyketides and Benzene Derivatives from Two Mangrove Sediment-Derived Fungi in the Beibu Gulf
作者：Peng, Bo;Cai, Jian;Li, Xinlong;Yang, Bin;Chen, Chunmei;Zhou, Xuefeng;Xiao, Zimin;Tao, Huaming;Liu, Manli;Fang, Wei;Huang, Yi-You
关键词：mangrove sediment-derived fungi; polyketide; stachylines; biological activity
-
Highly efficient construction of multi-substituted aminopyrazoles derivatives via iodine-mediated three-components reaction as potential anticancer agents
作者：Gao, Zilin;Liu, Manli;Shi, Liqiao;Zhang, Zhigang;Yang, Fei;Wang, Kaimei;Ke, Shaoyong;Gao, Zilin;Chen, Yu;Cao, Xiufang;Huang, Wenbo;Yang, Fei;Cao, Xiufang;Wang, Kaimei;Ke, Shaoyong
关键词：Aminipyrazole derivatives; three-component reaction; reaction mechanism; biological application; SARs; kinase inhibitor; molecular docking
