The effects of binary mixtures of estradiol and progesterone on transcriptional expression profiles of genes involved in hypothalamic-pituitary-gonadal axis and circadian rhythm signaling in embryonic zebrafish (Danio rerio)
文献类型： 外文期刊
作者： Liang, Yan-Qiu 1 ; Huang, Guo-Yong 2 ; Zhen, Zhen 3 ; Tian, Fei 4 ; Hou, Liping 5 ; Lin, Zhong 1 ; Ying, Guang-Guo 2 ;
作者机构： 1.Guangdong Ocean Univ, Fac Chem & Environm Sci, Zhanjiang 524088, Peoples R China
2.South China Normal Univ, Environm Res Inst, MOE Key Lab Environm Theoret Chem, Guangzhou 510006, Guangdong, Peoples R China
3.Guangdong Ocean Univ, Agr Coll, Zhanjiang 524088, Peoples R China
4.Chinese Acad Fishery Sci, South China Sea Fisheries Res Inst, Guangzhou 510300, Guangdong, Peoples R China
5.Guangzhou Univ, Sch Life Sci, Guangzhou 510655, Guangdong, Peoples R China
关键词： Hypothalamic-pituitary-gonadal axis; Circadian rhythm signaling; Mixture effects; Estradiol; Progesterone
期刊名称：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY （ 影响因子：6.291； 五年影响因子：6.393 ）
ISSN： 0147-6513
年卷期： 2019 年 174 卷
页码：
收录情况： SCI
摘要： Natural and synthetic estrogens and progestins are present in the various aquatic environments, leading to potential exposure of aquatic organisms to their mixtures. However, very little is known about their combined effects in aquatic organisms. The aim of this study was to analyze the effects of binary mixtures of estradiol (E2) and progesterone (P4) by measuring transcriptional changes of up to 42 selected target genes related to hypothalamic -pituitary-gonadal axis and circadian rhythm signaling in zebrafish (Danio rerio) eleuthero-embryos. Zebrafish embryos were exposed to E2 and P4 alone or in combination at concentrations between 45 and 5217 ngL(-1) for 96 h post fertilization (hpf). The results showed that P4 led to slight up-regulation of the cyp 1 1 a1, hsd1 7b3 and fshb transcripts, while a strong induction of cyp19a1b and Ihb mRNA by E2 was observed. Also, cyp19a1b and lhb mRNAs expression were strongly up-regulated in the mixtures, which were the same to E2 alone. This finding suggests the mixture activity of E2 and P4 followed the independent action in zebrafish eleuthero-embryos. These transcriptional alterations may translate to adverse effects on sex differentiation and reproduction in fish.
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