Facile synthesis of Silicon quantum dot-Gadolinium: A potential fluorescent/T1-T2 multimodal imaging agent
文献类型： 外文期刊
作者： Xiao, Fangnan 2 ; Xiao, Yue 1 ; Chen, Fangman 1 ; Liu, Xiaolin 1 ; Lin, Chentao 5 ; Chen, Jianxin 3 ; Wu, Yunkun 2 ;
作者机构： 1.Chinese Acad Sci, Fujian Inst Res Struct Matter, State Key Lab Struct Chem, Fuzhou 350002, Fujian, Peoples R China
2.Fujian Normal Univ, Coll Life Sci, Prov Univ Key Lab Cellular Stress Response & Meta, Fuzhou 350119, Fujian, Peoples R China
3.Fujian Normal Univ, Minist Educ, Key Lab OptoElect Sci & Technol Med, Fuzhou 350007, Fujian, Peoples R China
4.Fujian Agr & Forestry Univ, Sch Life Sci, Fuzhou 350002, Fujian, Peoples R China
5.Fujian Acad Agr Sci, Inst Biotechnol, Dept Immunol, Fuzhou 350003, Fujian, Peoples R China
关键词： SiQD-Gd; MRI; Fluorescence; Multimodal imaging
期刊名称：TALANTA （ 影响因子：6.057； 五年影响因子：5.386 ）
ISSN： 0039-9140
年卷期： 2019 年 199 卷
页码：
收录情况： SCI
摘要： Highly stable and multifunctional fluorescent quantum dots are particularly attractive in practical applications. Here, a new kind of ultra-small-sized silicon quantum dot-gadolinium (SiQD-Gd) was successfully fabricated by a newly-designed facile hydrothermal growth and chelating method. The obtained SiQD-Gd exhibited outstanding water dispersibility, stability and good fluorescent property with the quantum yield of 11.6%. SiQD-Gd displayed a low cytotoxicity in normal cell lines (HELF, HEK293F) and tumor cell lines (H1299, A549). Meanwhile, SiQD-Gd showed excellent magnetic resonance response with r(1) relaxation rate of 10.5 mmol L-1.s(-1) and r(2) relaxation rate of 47.5 mmol L-1.S-1, which are 2.5 and 7.4 times enhanced comparing to that of the commercial MR agent Magnevist. In vivo studies showed significant contrast enhancement effect of its T-1 and T-2-weighted MR imaging. In addition, in vivo fluorescent imaging for mice and zebrafish indicated its potential applications in fluorescent tracking. Thus, the excellent multimodal imaging capacity and biocompatibility of SiQD-Gd make it a potential imaging agent for clinic applications.
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