Citrus Flavanones Enhance beta-Carotene Uptake in Vitro Experiment Using Caco-2 Cell: Structure-Activity Relationship and Molecular Mechanisms
文献类型： 外文期刊
作者： Zhang, Zhongyuan 1 ; Nie, Meimei 1 ; Liu, Chunquan 1 ; Jiang, Ning 1 ; Liu, Chunju 1 ; Li, Dajing 1 ;
作者机构： 1.Jiangsu Acad Agr Sci, Inst Agroprod Proc, Nanjing 210014, Jiangsu, Peoples R China
2.Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang 212013, Jiangsu, Peoples R China
3.Nanjing Agr Univ, Coll Food & Technol, Nanjing 210095, Jiangsu, Peoples R China
关键词： citrus flavanone; beta-carotene; cellular uptake; structure-activity relationship; mechanism
期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：5.279； 五年影响因子：5.269 ）
ISSN： 0021-8561
年卷期： 2019 年 67 卷 15 期
页码：
收录情况： SCI
摘要： Flavonoids can interfere with the absorption of carotenoids. In this study, the inherent mechanisms of 12 citrus flavanones for beta-carotene (Bc) cellular uptake and the structure-activity relationship were investigated. The results showed that multiple hydroxyl groups had the lowest promoting effect. O-Glycosylation at C7 of the A ring led to the greatest promoting effect on Bc absorption. O-Glycosylation at C7 exhibited a strong affinity with the cell membrane and subsequently fluidized the cell membrane. Aglycon molecules significantly induced transient increases of paracellular permeability by decreasing tight junction proteins (ZO-1, claudin-1) expression. In addition, citrus flavanones might enhance scavenger receptor class B type I (SR-BI) expression via their actions as agonists of peroxisome proliferator-activated receptor-gamma (PPAR gamma). Catechol structure in the B-ring attenuated the activate action of SR-BI expression. The structure-dependent membrane permeability and activation of specific membrane proteins are mechanistically associated with the promoting effect on Bc cellular uptake by citrus flavanones.
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