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Encapsulation of pterostilbene in pea protein isolate-fucoidan-quaternary ammonium chitosan complex nanoparticles to enhance its stability, antioxidant activity and intestinal permeability

文献类型： 外文期刊

作者： Liu, Qianyuan 1 ; Wang, Zihan 1 ; Kan, Jia 1 ; Sun, Rongxue 1 ; Wang, Cheng 1 ; Jiang, Ning 1 ;

作者机构： 1.Jiangsu Acad Agr Sci, Inst Agr Prod Proc, Nanjing 210014, Jiangsu, Peoples R China

2.Minist Agr & Rural Affairs, Integrated Sci Res Base Preservat Storage & Proc, Nanjing 210014, Jiangsu, Peoples R China

关键词： Pterostilbene; Pea protein isolate; Fucoidan; Quaternary ammonium chitosan; Complex nanoparticles; Delivery system

期刊名称：FOOD HYDROCOLLOIDS （ 影响因子：12.4； 五年影响因子：13.3 ）

ISSN： 0268-005X

年卷期： 2025 年 164 卷

页码：

收录情况： SCI

摘要： Pterostilbene (PS) is a hydrophobic phenolic compound with favorable health benefits, but low water solubility and chemical instability of PS restrict its application. This study developed pea protein isolate (PPI)-fucoidan (FU)-quaternary ammonium chitosan (QAC) nanoparticles (NPs) as nanocarriers for the encapsulation, protection, and delivery of PS. The preparation of PS-PPI-FU-QAC-NPs involved two-step processes: pH change-induced self-assembly of PS-PPI-FU-NPs, followed by electrostatic deposition of QAC. The optimal mass ratio of PPI:FU: QAC:PS was 1:0.5:3:0.1 based on the analysis of particle size, zeta-potential, and encapsulation efficiency. The resulting PS-PPI-FU-QAC-NPs displayed nanoscale spherical structure, uniform distribution (PDI <0.3), average size of 244.2 nm, zeta-potential of 31.3 mV, and high PS encapsulation efficiency of 95.5%. The assembly of PS-PPIFU-QAC-NPs was driven by multiple intermolecular interactions, including hydrophobic, hydrogen-bonding, electrostatic, and steric interactions. The addition of FU and QAC significantly enhanced the physicochemical stability of PS-PPI-NPs. PS-PPI-FU-QAC-NPs displayed exceptional colloidal stability under pH range of 2.0-8.0 and NaCl concentration up to 2.0 mol/L. Meanwhile, PS-PPI-FU-NPs and PS-PPI-FU-QAC-NPs demonstrated superior PS retention under UV and thermal conditions compared to free-form PS and PS-PPI-NPs, as well as modulated the release behavior of PS during simulated gastrointestinal digestion. Furthermore, PS-PPI-FU-QACNPs exhibited higher free radical scavenging capacity and intestinal permeability for PS in Caco-2 cell monolayer than free-form PS and other nano-formulations. These findings demonstrate the potential of PPI-FU-QAC-NPs to enhance water solubility, chemical stability, intestinal permeability, and biological activities of PS, offering a novel and advantageous technique for delivering bioactive ingredients.

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