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Characterization of an NDM-5 carbapenemase-producing Escherichia coli ST156 isolate from a poultry farm in Zhejiang, China

文献类型： 外文期刊

作者： Tang, Biao 1 ; Chang, Jiang 1 ; Cao, Liujie 1 ; Luo, Qixia 3 ; Xu, Hao 3 ; Lyu, Wentao 1 ; Qian, Mingrong 1 ; Ji, Xiaofen 1 ;

作者机构： 1.Zhejiang Acad Agr Sci, Inst Qual & Stand Agroprod, Hangzhou 310021, Zhejiang, Peoples R China

2.Northwest Agr & Forestry Univ, Coll Food Sci & Engn, Yangling 712100, Shaanxi, Peoples R China

3.Zhejiang Univ, Affiliated Hosp 1, State Key Lab Diag & Treatment Infect Dis,Med Sch, Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310003, Zhejiang, Peoples R China

4.Zhejiang Acad Agr Sci, State Key Lab Breeding Base Zhejiang Sustainable, Hangzhou 310021, Zhejiang, Peoples R China

关键词： bla(NDM-5); Carbapenemase; Escherichia coli; Multidrug resistance; Poultry farm

期刊名称：BMC MICROBIOLOGY （ 影响因子：3.605； 五年影响因子：4.283 ）

ISSN： 1471-2180

年卷期： 2019 年 19 卷

页码：

收录情况： SCI

摘要： BackgroundThe emergence of carbapenem-resistant Enterobacteriaceae strains has posed a severe threat to public health in recent years. The mobile elements carrying the New Delhi metallo--lactqtamase (NDM) gene have been regarded as the major mechanism leading to the rapid increase of carbapenem-resistant Enterobacteriaceae strains isolated from clinics and animals.ResultsWe describe an NDM-5-producing Escherichia coli strain, ECCRA-119 (sequence type 156 [ST156]), isolated from a poultry farm in Zhejiang, China. ECCRA-119 is a multidrug-resistant (MDR) isolate that exhibited resistance to 27 antimicrobial compounds, including imipenem and meropenem, as detected by antimicrobial susceptibility testing (AST). The complete genome sequence of the ECCRA-119 isolate was also obtained using the PacBio RS II platform. Eleven acquired resistance genes were identified in the chromosome; four were detected in plasmid pTB201, while six were detected in plasmid pTB202. Importantly, the carbapenem-resistant gene bla(NDM-5) was detected in the IncX3 plasmid pTB203. In addition, seven virulence genes and one metal-resistance gene were also detected. The results of conjugation experiments and the transfer regions identification indicated that the bla(NDM-5)-harboring plasmid pTB203 could be transferred between E. coli strains.ConclusionsThe results reflected the severe bacterial resistance in a poultry farm in Zhejiang province and increased our understanding of the presence and transmission of the bla(NDM-5) gene.

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