中国热带农业科学院机构知识库

Bialternacins A-F, Aromatic Polyketide Dimers from an Endophytic Alternaria sp.

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文献类型：外文期刊

作者： Yang, Cheng Long ¹ ; Wu, Hui Min ¹ ; Liu, Cheng Li ¹ ; Zhang, Xuan ¹ ; Guo, Zhi Kai ³ ; Chen, Yu ⁴ ; Liu, Fang ⁴ ; Liang, ¹ ;

作者机构： 1.Nanjing Univ, Inst Funct Biomol, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China

2.Nanjing Univ Chinese Med, State Key Lab Cultivat Base TCM Qual & Efficacy, Nanjing 210023, Jiangsu, Peoples R China

3.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Minist Agr, Key Lab Biol & Genet Resources Trop Crops, Haikou 571101, Hainan, Peoples R China

4.Nanjing Univ, Sch Chem & Chem Engn, Jiangsu Key Lab Adv Organ Mat, State Key Lab Coordinat Chem, Nanjing 210023, Jiangsu, Peoples R China

期刊名称：JOURNAL OF NATURAL PRODUCTS （影响因子：4.05；五年影响因子：4.603 ）

ISSN： 0163-3864

年卷期： 2019 年 82 卷 4 期

页码：

收录情况： SCI

摘要： Six novel aromatic polyketide dimers, bialternacins A-F (1-6), were isolated from a plant endophytic Alternaria sp. The structures of compounds 1-6 were elucidated on the basis of extensive spectroscopic analysis, single-crystal X-ray diffraction, and electronic circular dichroism analysis. Compounds 1, 2, 5, and 6 were characterized as four pairs of racemic mixtures. Compound (+)-5 was demonstrated to show acetylcholinesterase inhibitory activity with an IC50 value of 15.5 mu M. A putative biosynthetic pathway for these compounds was proposed.

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Bialternacins A-F, Aromatic Polyketide Dimers from an Endophytic Alternaria sp.

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