文献类型： 外文期刊
作者： Yang, Cheng Long 1 ; Wu, Hui Min 1 ; Liu, Cheng Li 1 ; Zhang, Xuan 1 ; Guo, Zhi Kai 3 ; Chen, Yu 4 ; Liu, Fang 4 ; Liang, 1 ;
作者机构： 1.Nanjing Univ, Inst Funct Biomol, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China
2.Nanjing Univ Chinese Med, State Key Lab Cultivat Base TCM Qual & Efficacy, Nanjing 210023, Jiangsu, Peoples R China
3.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Minist Agr, Key Lab Biol & Genet Resources Trop Crops, Haikou 571101, Hainan, Peoples R China
4.Nanjing Univ, Sch Chem & Chem Engn, Jiangsu Key Lab Adv Organ Mat, State Key Lab Coordinat Chem, Nanjing 210023, Jiangsu, Peoples R China
期刊名称：JOURNAL OF NATURAL PRODUCTS （ 影响因子：4.05； 五年影响因子：4.603 ）
ISSN： 0163-3864
年卷期： 2019 年 82 卷 4 期
页码：
收录情况： SCI
摘要： Six novel aromatic polyketide dimers, bialternacins A-F (1-6), were isolated from a plant endophytic Alternaria sp. The structures of compounds 1-6 were elucidated on the basis of extensive spectroscopic analysis, single-crystal X-ray diffraction, and electronic circular dichroism analysis. Compounds 1, 2, 5, and 6 were characterized as four pairs of racemic mixtures. Compound (+)-5 was demonstrated to show acetylcholinesterase inhibitory activity with an IC50 value of 15.5 mu M. A putative biosynthetic pathway for these compounds was proposed.
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