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Anti-inflammatory activity of polysaccharides from Phellinus linteus by regulating the NF-kappa B translocation in LPS-stimulated RAW264.7 macrophages

文献类型： 外文期刊

作者： Xie, Zhenglu 1 ; Wang, Yang 1 ; Huang, Juqing 2 ; Qian, Ning 1 ; Shen, Guozhi 1 ; Chen, Linghua 1 ;

作者机构： 1.Fujian Agr & Forestry Univ, Jinshan Coll, 15 Shangxiadian Rd, Fuzhou 350002, Fujian, Peoples R China

2.Fujian Acad Agr Sci, Inst Agr Engn & Technol, Fuzhou, Fujian, Peoples R China

关键词： Phellinus linteus; Polysaccharides; Anti-inflammatory; NF-kappa B; RAW264.7 macrophages

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：6.953； 五年影响因子：6.737 ）

ISSN： 0141-8130

年卷期： 2019 年 129 卷

页码：

收录情况： SCI

摘要： Inflammatory response remains one of the most common and serious complications of disease. In order to profound understanding relationship between Phellinus linteus polysaccharides (TCM) and inflammation, inflammatory cell model was constructed by LPS acting RAW264.7 cell line. The results showed that TCM could decrease the pro-inflammatory cytokines (TNF-alpha, IL-1 beta, IL-2, IL-6 and IL-12) contents and the mRNA expression levels and increase the anti-inflammatory cytokines (IL-4 and IL-10) contents and the mRNA expression levels. Additionally, the levels of NF-kappa B translocation was significantly decreased, which associated with the I kappa B alpha phosphorylation level decreased and the AMPK alpha phosphorylation level increased. These results indicated that TCM could reduce the inflammatory responses in the LPS induced inflammatory cell model might be related to inhibit NF-kappa B translocation and regulate the balance of anti-inflammatory and pro-inflammatory factors. (C) 2019 Elsevier B.V. All rights reserved.

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