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Pharmacokinetic/pharmacodynamic properties and P-glycoprotein expression in pacific white shrimp, Litopenaeus vannamei after oral administration at three dosages of oxolinic acid

文献类型： 外文期刊

作者： Fu, Guihong 1 ; Yin, Guifang 1 ; Wang, Yuan 1 ; Zhou, Junfang 1 ; Zhao, Shu 1 ; Li, Xincang 1 ; Fang, Wenhong 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Key Lab East China Sea Fishery Resources Exploita, Minist Agr & Rural Affair, East China Sea Fisheries Res Inst, Shanghai, Peoples R China

关键词： Litopenaeus vannamei; oxolinic acid; P-glycoprotein; pharmacodynamics; pharmacokinetics

期刊名称：AQUACULTURE RESEARCH （ 影响因子：2.082； 五年影响因子：2.415 ）

ISSN： 1355-557X

年卷期： 2019 年 50 卷 6 期

页码：

收录情况： SCI

摘要： The experiments explored the pharmacokinetics (PK) properties of oxolinic acid (OXA) after oral administration at three dosages (10, 30 and 80 mg/kg) via medicated feed in the shrimp. The results showed that the C-max values of 4.31, 14.93 and 16.62 mg/L and AUC(0-infinity) values of 92.61, 252.30 and 364.27 mg hr(-1) L-1 were observed at three OXA dosage groups in the haemolymph respectively. In the hepatopancreas, C-max values of 7.90, 27.23 and 60.51 mg/kg and AUC(0-infinity) values of 42.01, 133.06 and 219.06 mg hr(-1) L-1 were observed at 0.5 hr post administration respectively. In the muscle, C-max values of 1.62, 5.80 and 7.36 mg/kg and the AUC(0-infinity) values of 25.64, 98.10 and 134.24 mg hr(-1) L-1 were observed at 2 hr post administration respectively. In the gills, C-max values of 2.87, 8.08 and 12.12 mg/kg and the AUC(0-infinity) values of 51.38, 118.65 and 206.48 mg hr(-1) L-1 were observed at 4 hr post administration respectively. In addition, the in vitro MIC values of OXA at three dosages against 132 strains of Vibrio were examined and showed that the minimum inhibitory concentration (MIC) values for OXA primarily ranged from 0.15-1.25 mu g/ml, including eight strains of Vibrio showing MIC values >= 5 mu g/ml. The MIC50 and MIC90 values of 132 strains were 0.62 and 1.25 mu g/ml respectively. The AUC(0-24)/MIC90 ratios of Vibrio were 140.4 in 30 mg/kg group. Furthermore, the P-glycoprotein (P-gp) expression was determined in shrimp tissues after administration to three dosage groups (10, 30 and 80 mg/kg). The results showed that P-gp expression was up-regulated in the hepatopancreas (5.36-, 13.68- and 31.06-fold respectively) compared with the control group.

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